Antisense basic fibroblast growth factor oligonucleotide reduced adhesion of retinal pigment epithelial cells to extracellular matrix molecules and their proliferation

被引：2

作者：

Rho, SH

Yoon, HS

Yoo, KW

Park, WC

Jeong, JH

Yoo, YH

机构：

[1] Dong A Univ, Coll Med, Dept Anat & Cell Biol, Pusan 602103, South Korea

[2] Dong A Univ, Coll Med, Dept Ophthalmol, Pusan 602103, South Korea

[3] Inst Med Sci, Pusan, South Korea

来源：

OPHTHALMIC RESEARCH | 2001年 / 33卷 / 01期

关键词：

retinal pigment epithelium; basic fibroblast growth factor; antisense oligonucleotide; adhesion; proliferation;

D O I：

10.1159/000055637

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

We investigated the effect of extracellular matrix molecules on the adhesion of retinal pigment epithelial cells and their subsequent proliferation. Fibronectin, collagen type I and vitronectin enhanced their adhesion and proliferation. In addition, the effect of basic fibroblast growth factor (bFGF) on their adhesion and proliferation was studied. bFGF enhanced their adhesion and proliferation, whereas antisense bFGF reduced their adhesion to and their proliferation on extracellular matrix molecules. Copyright (C) 2001 S. Karger AG, Basel.

引用

页码：24 / 30

页数：7

共 22 条

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