Autophagy-monitoring and autophagy-deficient mice

被引：325

作者：

Kuma, Akiko ^{[1
,2
,3
]}

Komatsu, Masaaki ^{[4
]}

Mizushima, Noboru ^{[1
,2
]}

机构：

[1] Univ Tokyo, Grad Sch, Dept Biochem & Mol Biol, Tokyo, Japan

[2] Univ Tokyo, Fac Med, Tokyo, Japan

[3] Natl Canc Ctr, Res Inst, Div Canc Biol, Tokyo, Japan

[4] Niigata Univ, Grad Sch Med & Dent Sci, Dept Biochem, Niigata, Japan

来源：

AUTOPHAGY | 2017年 / 13卷 / 10期

基金：

日本学术振兴会;

关键词：

autophagy; knockout mouse; mitophagy; reporter mouse; selective autophagy; CAENORHABDITIS-ELEGANS; KINASE UNC-51; IN-VIVO; SELECTIVE AUTOPHAGY; SERINE/THREONINE KINASE; OPTINEURIN DEFICIENCY; AXONAL ELONGATION; UBIQUITIN; PROTEIN; GENE;

D O I：

10.1080/15548627.2017.1343770

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Discovery of yeast autophagy-related (ATG) genes and subsequent identification of their homologs in other organisms have enabled researchers to investigate physiological functions of macroautophagy/autophagy using genetic techniques. Specific identification of autophagy-related structures is important to evaluate autophagic activity, and specific ablation of autophagy-related genes is a critical means to determine the requirements of autophagy. Here, we review currently available mouse models, particularly focusing on autophagy (and mitophagy) indicator models and systemic autophagy-related gene-knockout mouse models.

引用

页码：1619 / 1628

页数：10

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