Autophagy-monitoring and autophagy-deficient mice

被引：325
作者：
Kuma, Akiko [1 ,2 ,3 ]
Komatsu, Masaaki [4 ]
Mizushima, Noboru [1 ,2 ]
机构：
[1] Univ Tokyo, Grad Sch, Dept Biochem & Mol Biol, Tokyo, Japan
[2] Univ Tokyo, Fac Med, Tokyo, Japan
[3] Natl Canc Ctr, Res Inst, Div Canc Biol, Tokyo, Japan
[4] Niigata Univ, Grad Sch Med & Dent Sci, Dept Biochem, Niigata, Japan
来源：
AUTOPHAGY | 2017年 / 13卷 / 10期
基金：
日本学术振兴会;
关键词：
autophagy; knockout mouse; mitophagy; reporter mouse; selective autophagy; CAENORHABDITIS-ELEGANS; KINASE UNC-51; IN-VIVO; SELECTIVE AUTOPHAGY; SERINE/THREONINE KINASE; OPTINEURIN DEFICIENCY; AXONAL ELONGATION; UBIQUITIN; PROTEIN; GENE;
D O I：
10.1080/15548627.2017.1343770
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Discovery of yeast autophagy-related (ATG) genes and subsequent identification of their homologs in other organisms have enabled researchers to investigate physiological functions of macroautophagy/autophagy using genetic techniques. Specific identification of autophagy-related structures is important to evaluate autophagic activity, and specific ablation of autophagy-related genes is a critical means to determine the requirements of autophagy. Here, we review currently available mouse models, particularly focusing on autophagy (and mitophagy) indicator models and systemic autophagy-related gene-knockout mouse models.
引用
收藏
页码：1619 / 1628
页数：10
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