Antimicrobial properties of nitric oxide and its application in antimicrobial formulations and medical devices

被引:158
作者
Jones, Mitchell Lawrence [1 ]
Ganopolsky, Jorge Gabriel [2 ]
Labbe, Alain [2 ]
Wahl, Christopher [2 ]
Prakash, Satya [1 ]
机构
[1] McGill Univ, Biomed Technol & Cell Therapy Res Lab, Dept Biomed Engn & Physiol, Artificial Cells & Organs Res Ctr,Fac Med, Montreal, PQ H3A 2B4, Canada
[2] Univ Quebec Montreal, Micropharma Ltd, Montreal, PQ H2X 3Y7, Canada
关键词
Nitric oxide; Antimicrobial; Bactericidal; Fungicidal; Bacteria; Infection; Wound healing; Patch; Dressing; Device; STAPHYLOCOCCUS-AUREUS; ACIDIFIED NITRITE; NITROGEN-OXIDES; SKIN; PEROXYNITRITE; BACTERIA; NITRATE; NO; RESISTANT; DELIVERY;
D O I
10.1007/s00253-010-2733-x
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
This review describes the antimicrobial properties of nitric oxide (NO) and its application as an antimicrobial agent in different formulations and medical devices. We depict the eukaryotic biosynthesis of NO and its physiologic functions as a cell messenger and as an antimicrobial agent of the cell-mediated immune response. We analyze the antimicrobial activity of NO and the eukaryotic protective mechanisms against NO for the purpose of delineating the therapeutic NO dosage range required for an efficacious and safe antimicrobial activity. We also examine the role of NO produced by virulent bacteria in lessening the efficacy of traditional antimicrobials. In addition, we discuss the efficacy of NO in the healing of infected wounds, describing different NO-producing devices by category, analyzing therapeutic levels, duration of NO production, as well as commercial considerations. Finally, we provide current and future prospects for the design and use of NO-producing devices.
引用
收藏
页码:401 / 407
页数:7
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