Genetic Testing of the Hypothesis That Hybrid Male Lethality Results From a Failure in Dosage Compensation

被引：15

作者：

Barbash, Daniel A. ^{[1
]}

机构：

[1] Cornell Univ, Dept Mol Biol & Genet, Ithaca, NY 14853 USA

来源：

GENETICS | 2010年 / 184卷 / 01期

基金：

美国国家卫生研究院;

关键词：

DROSOPHILA-MELANOGASTER; SPECIES HYBRIDS; POSITIVE SELECTION; INVIABLE HYBRIDS; SIMULANS; COMPLEX; RESCUE; HP1; MISREGULATION; INVIABILITY;

D O I：

10.1534/genetics.109.108100

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Several recent studies have suggested that F(1) hybrid male lethality in crosses between Drosophila melanogaster and D. simulans is due to a failure in dosage compensation, caused by incompatibilities between D. simulans dosage compensation proteins and the D. melanogaster X chromosome. Contrary to the predictions of this hypothesis, mutations in four essential D. melanogaster dosage compensation genes are shown here to moderately increase rather than decrease hybrid male viability.

引用

页码：313 / 316

页数：4

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