Comparative Antigenicity and Pathogenicity of Two Distinct Genotypes of Highly Pathogenic Avian Influenza Viruses (H5N8) From Wild Birds in China, 2020-2021

被引：3

作者：

Jiang, Wenming ^{[1
]}

Liu, Shuo ^{[1
]}

Yin, Xin ^{[1
]}

Li, Zhixin ^{[2
]}

Lan, Zouran ^{[3
]}

Xire, Luosong ^{[4
]}

Wang, Zhongbing ^{[5
]}

Xie, Yinqian ^{[6
]}

Peng, Cheng ^{[1
]}

Li, Jinping ^{[1
]}

Hou, Guangyu ^{[1
]}

Yu, Xiaohui ^{[1
]}

Sun, Rongzhao ^{[1
]}

Liu, Hualei ^{[1
]}

机构：

[1] China Anim Hlth & Epidemiol Ctr, Qingdao, Peoples R China

[2] Ningxia Hui Autonomous Reg Anim Dis Prevent & Cont, Yinchuan, Peoples R China

[3] Shandong Prov Ctr Anim Dis Control, Jinan, Peoples R China

[4] Tibet Autonomous Reg Vet Biol Pharmaceut Factory, Lhasa, Peoples R China

[5] Shanxi Anim Dis Prevent & Control Ctr, Taiyuan, Peoples R China

[6] Shaanxi Anim Dis Prevent & Control Ctr, Xian, Peoples R China

来源：

FRONTIERS IN MICROBIOLOGY | 2022年 / 13卷

关键词：

highly pathogenic avian influenza; wild birds; genetic; pathogenicity; antigenicity; AMINO-ACID SUBSTITUTION; CLADE; 2.3.4.4; NS1; PROTEIN; A VIRUS; A(H5N8) VIRUS; PROTECTIVE EFFICACY; MIGRATORY BIRDS; VIRULENCE; OUTBREAKS; HEMAGGLUTININ;

D O I：

10.3389/fmicb.2022.893253

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

To date, there have been three epidemic waves of H5N8 avian influenza worldwide. The current third epidemic wave began in October 2020 and has expanded to at least 46 countries. Active and passive surveillance were conducted to monitor H5N8 viruses from wild birds in China. Genetic analysis of 10 H5N8 viruses isolated from wild birds identified two different genotypes. Animal challenge experiments indicated that the H5N8 isolates are highly pathogenic in chickens, mildly pathogenic in ducks, while pathogenicity varied in BALB/c mice. Moreover, there were significant differences in antigenicity as compared to Re-11 vaccine strain and vaccinated chickens were not completely protected against challenge with the high dose of H5N8 virus. With the use of the new matched vaccine and increased poultry immune density, surveillance should be intensified to monitor the emergence of mutant strains and potential worldwide spread via wild birds.

引用

页数：11

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