Delta/notch-like epidermal growth factor-related receptor (DNER) orchestrates stemness and cancer progression in prostate cancer

被引：1
作者：
Wang, Lijun [1 ]
Wu, Qi [1 ]
Zhu, Shan [1 ]
Li, Zhiyu [1 ]
Yuan, Jingping [2 ]
Yu, Dehua [2 ,3 ]
Xu, Zhiliang [1 ]
Li, Juanjuan [1 ]
Sun, Shengrong [1 ]
Wang, Changhua [3 ]
机构：
[1] Wuhan Univ, Renmin Hosp, Dept Breast & Thyroid Surg, 99 Zhang Zhidong Rd, Wuhan 430060, Hubei, Peoples R China
[2] Wuhan Univ, Renmin Hosp, Dept Pathol, Wuhan, Hubei, Peoples R China
[3] Wuhan Univ, Sch Basic Med Sci, Dept Pathophysiol, Wuhan 430060, Hubei, Peoples R China
来源：
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH | 2017年 / 9卷 / 11期
关键词：
DNER; prostate cancer; stemness; proliferation; metastasis; BREAST-CANCER; POOR-PROGNOSIS; NOTCH LIGAND; CELLS; PROLIFERATION; EXPRESSION; TARGET; INHIBITION; INVASION; HEDGEHOG;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
DNER, Delta/Notch-like epidermal growth factor (EGF)-related receptor, is a neuron-specific transmembrane protein carrying extracellular EGF-like repeats. The function of DNER in prostate cancer has not been evaluated. Here, we showed that the upregulation of DNER is observed in various cancers, including prostate cancer. Knockdown of DNER in PC-3 cells inhibited cell proliferation, migration and invasion as well as tumorigenesis in PC-3 xenografts. DNER knockdown specifically inhibited cell growth in spheroids. RT-PCR and western blot analysis were performed, and CD44, HES1 and GLI1 expression was significantly decreased in DNER knockdown cells. Thus, DNER promotes prostate cancer progression and the growth of PC-3 cells by modulating the primary genes of cancer stem cells.
引用
收藏
页码：5031 / 5039
页数：9
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