K2S2O8-Mediated Synthesis of Highly Functionalized Pyrroles via Oxidative Self-Dimerization of N-Propargylamines

被引：21

作者：

Behera, Bipin Kumar ^{[1
]}

Sahu, Archana Kumari ^{[1
]}

Devi, Ngangbam Renubala ^{[1
]}

Saikia, Anil K. ^{[1
]}

机构：

[1] Indian Inst Technol Guwahati, Dept Chem, Gauhati 781039, India

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2021年 / 86卷 / 18期

关键词：

ALIPHATIC CARBOXYLIC-ACIDS; CATALYZED DECARBOXYLATIVE ALKYNYLATION; RADICAL TANDEM CYCLIZATION; SUBSTITUTED PYRROLES; TERMINAL ALKYNES; H BOND; C-C; WATER; TRIFLUOROMETHYLTHIOLATION; DERIVATIVES;

D O I：

10.1021/acs.joc.1c00471

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient methodology has been developed for the synthesis of tetra- and pentasubstituted pyrroles via oxidative self-dimerization of N-propargylamines catalyzed by silver benzoate in the presence of K2S2O8 in good yields. The protocol provides a simple route for the synthesis of both tetra- and pentasubstituted pyrroles with two carbonyl groups in the side chain. The methodology can be extended toward the synthesis of pyrrolo-[3,4-d]pyridazine.

引用

页码：12481 / 12493

页数：13

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