Thromboelastography predicting the prognosis of sudden sensorineural hearing loss

Objectives To explore the association between thromboelastography and the clinical features as well as the prognosis of sudden sensorineural hearing loss (SSNHL). Design Single-centre, retrospective study. Setting A hospital in China. Participants In total, 133 patients presented with SSNHL within 2 weeks before the study, who did not receive treatment. Main Outcome Measures The patients' medical history was collected. Audiological, imaging and haematological examinations were performed before treatment. Patients with abnormal thromboelastography were re-examined 1 week after treatment, and efficacy was evaluated 1 month after treatment. The chi-squared test and binary logistic regression analysis were used to analyse the association between factors, such as vertigo, degree and type of hearing loss, vestibular function, inner ear MRI results, thromboelastography and efficacy of treatment. Results Thromboelastography was correlated with prognosis (p = 0.049) and degree (p = 0.030) and type of hearing loss (p = 0.013) in patients with SSNHL. The R (p = 0.002) and angle values (p = 0.010) correlated with prognosis. The MA (p = 0.022) and G values (p = 0.020) correlated with the degree of hearing loss. The R (p = 0.033) value correlated with inner ear MRI results, and the Delta G (p = 0.010) value correlated with fibrinogen levels. Delta Thromboelastography (p = 0.032) was correlated with the prognosis of patients with abnormal thromboelastography results. Logistic regression analysis showed that thromboelastography correlated with prognosis (p = 0.013), and Delta thromboelastography correlated with the prognosis of patients with abnormal thromboelastography results (p = 0.013) and vertigo (p = 0.016). Conclusion Thromboelastography is an independent risk factor affecting the prognosis of SSNHL with the R and angle values playing a major role.