Isolation of a family of organic anion transporters from human liver and kidney

被引：159

作者：

Sun, W ^{[1
]}

Wu, RR ^{[1
]}

van Poelje, PD ^{[1
]}

Erion, MD ^{[1
]}

机构：

[1] Metabasis Therapeut Inc, San Diego, CA 92121 USA

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2001年 / 283卷 / 02期

关键词：

organic anion; membrane transport; p-aminohippurate; liver transport; kidney transport;

D O I：

10.1006/bbrc.2001.4774

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Five distinct organic anion transporter cDNAs, hOAT1-, were isolated from human liver and kidney. hOAT1, 2, and 3 are homologous to their respective rat orthologues OAT1-3, whereas hOAT4 and 5 are novel clones that have not been identified in other species. hOAT1- and hOAT3-transfected cells showed uptake of p-aminohippurate and fluorescein. Cells expressing hOAT2 showed uptake of p-aminohippurate, methotrexate, cAMP, and alpha -ketoglutarate. Northern blot analysis indicated differential tissue distribution for the transporter transcripts. These results indicate the existence of a family of organic anion transporting proteins in humans distinct from the oatp-like family of transporters. (C) 2001 Academic Press.

引用

页码：417 / 422

页数：6

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