Ruthenium-Catalyzed Difluoroalkylation of 8-Aminoquinoline Amides at the C5-Position

被引：23

作者：

Chen, Changpeng ^{[1
,2
]}

Zeng, Runsheng ^{[3
]}

Zhang, Jingyu ^{[1
,2
]}

Zhao, Yingsheng ^{[3
]}

机构：

[1] Soochow Univ, Coll Phys Optoelect & Energy, Suzhou 215006, Peoples R China

[2] Soochow Univ, Collaborat Innovat Ctr Suzhou Nano Sci & Technol, Suzhou 215006, Peoples R China

[3] Soochow Univ, Key Lab Organ Synth Jiangsu Prov, Coll Chem Chem Engn & Mat Sci, Suzhou 215123, Peoples R China

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2017年 / 2017卷 / 46期

基金：

中国国家自然科学基金;

关键词：

Fluorinated Compounds; Fluorine; Synthetic methods; Homogeneous catalysis; Ruthenium; C-H FUNCTIONALIZATION; COPPER-MEDIATED DIFLUOROMETHYLATION; ARYL BORONIC ACIDS; DIRECTING GROUP; QUINOLINES; ARENES; SULFONYLATION; CHLORIDES; IODIDES; HALIDES;

D O I：

10.1002/ejoc.201701150

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A ruthenium-catalyzed highly selective difluoromethylation of 8-aminoquinoline amides at the C5 position has been developed. It tolerates a broad range of functional groups, providing the corresponding difluoromethylated products in moderate to good yields. Preliminary experimental results indicate that the tricoordinate ruthenium intermediate is the key factor in achieving the C5-position selectivity.

引用

页码：6947 / 6950

页数：4

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