Monitoring Ion Beam Therapy With a Compton Camera: Simulation Studies of the Clinical Feasibility

被引：31

作者：

Fontana, M. ^{[1
]}

Ley, J. -L. ^{[1
]}

Dauvergne, D. ^{[2
]}

Freud, N. ^{[3
]}

Krimmer, J. ^{[1
]}

Letang, J. M. ^{[3
]}

Maxim, V. ^{[3
]}

Richard, M. -H. ^{[1
]}

Rinaldi, I. ^{[1
]}

Testa, E. ^{[1
]}

机构：

[1] Univ Claude Bernard Lyon 1, CNRS IN2P3, Inst Phys Nucl Lyon, Univ Lyon, F-69622 Villeurbanne, France

[2] Univ Grenoble Alpes, CNRS, LPSC IN2P3, Grenoble INP, F-38000 Grenoble, France

[3] Univ Claude Bernard Lyon 1, CREATIS UMR 5220 U1206, Univ Lyon, CNRS,Inserm,Ctr Leon Berard,INSA Lyon,UJM St Etie, F-69373 Lyon, France

来源：

IEEE TRANSACTIONS ON RADIATION AND PLASMA MEDICAL SCIENCES | 2020年 / 4卷 / 02期

关键词：

Clinical applicability; Compton camera; ion therapy; prompt gamma (PG); IMAGE-RECONSTRUCTION; PROTON THERAPY; SLIT CAMERA; OPTIMIZATION; IRRADIATION; RESOLUTION; EMISSION; DESIGN;

D O I：

10.1109/TRPMS.2019.2933985

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

As more and more particle therapy centers are being built world-wide, there is increasing need in treatment monitoring methods, ideally in real time. This article investigates the clinical applicability of a Compton camera design by means of Monte Carlo simulations. The Compton camera performance has been studied with the simulation of point-like source and beam irradiation of a polymethyl methacrylate (PMMA) phantom. The system absolute photon detection efficiency, measured via source irradiation, varies in the range [1, 4] x 10(-4) with energy variations in the prompt gamma (PG) energy range and source position shifts with respect to the center of the camera. With proton and carbon beams impinging on a PMMA cylindrical phantom, the number of detected PG coincidences related to various beam time structure has been studied. Finally, the accuracy of the camera in identifying the dose profile fall-off position has been estimated and two different event reconstruction methods have been compared for this purpose; one based on analytical calculation with a line-cone technique, the second relying on an iterative maximum likelihood expectation maximization algorithm. Both methods showed the possibility to reconstruct the beam depth-dose profile and to retrieve the dose fall-off with millimeter precision on a spot basis.

引用

页码：218 / 232

页数：15

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