Functionalization of inorganic nanoparticles with polymers for stealth biomedical applications

被引：80

作者：

Neoh, Koon Gee ^{[1
]}

Kang, En Tang ^{[1
]}

机构：

[1] Natl Univ Singapore, Dept Chem & Biomol Engn, Kent Ridge 119260, Singapore

来源：

POLYMER CHEMISTRY | 2011年 / 2卷 / 04期

关键词：

IRON-OXIDE NANOPARTICLES; SURFACE-INITIATED POLYMERIZATION; TRANSFER RADICAL POLYMERIZATION; PEGYLATED GOLD NANOPARTICLES; SELF-ASSEMBLED MONOLAYERS; DRUG-DELIVERY SYSTEMS; MAGNETITE NANOPARTICLES; FE3O4; NANOPARTICLES; POLY(ETHYLENE GLYCOL); IN-VITRO;

D O I：

10.1039/c0py00266f

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Inorganic nanoparticles offer great opportunities in biomedicine, for example, serving as contrast agents for imaging, hyperthermia agents and drug delivery vehicles. A critical factor limiting the applications of nanoparticles for therapeutic and diagnostic purposes is their short circulation time in vivo due to clearance by the body's reticuloendothelial system. One of the most efficient strategies to confer stealthiness to nanoparticles is the use of a polymer "cloak" which inhibits plasma protein adsorption and recognition by the immune system. This review describes some of the polymers which are suitable for these applications, and the strategies which can be employed to functionalize inorganic nanoparticles with such polymers.

引用

页码：747 / 759

页数：13

共 82 条

[31] Antibiofouling polymer-coated gold nanoparticles as a contrast agent for in vivo x-ray computed tomography imaging [J].

Kim, Dongkyu ;

Park, Sangjin ;

Lee, Jae Hyuk ;

Jeong, Yong Yeon ;

Jon, Sangyong .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2007, 129 (24) :7661-7665

[32] A bifunctional poly(ethylene glycol) silane immobilized on metallic oxide-based nanoparticles for conjugation with cell targeting agents [J].

Kohler, N ;

Fryxell, GE ;

Zhang, MQ .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2004, 126 (23) :7206-7211

[33] Antibiofouling polymer-coated superparamagnetic iron oxide nanoparticles as potential magnetic resonance contrast agents for in vivo cancer imaging [J].

Lee, Haerim ;

Lee, Eunhye ;

Kim, Do Kyung ;

Jang, Nam Kyu ;

Jeong, Yong Yeon ;

Jon, Sangyong .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2006, 128 (22) :7383-7389

[34] One-pot reaction to synthesize biocompatible magnetite nanoparticles [J].

Li, Z ;

Wei, L ;

Gao, MY ;

Lei, H .

ADVANCED MATERIALS, 2005, 17 (08) :1001-+

[35] One-pot synthesis of PEGylated ultrasmall iron-oxide nanoparticles and their in vivo evaluation as magnetic resonance imaging contrast agents [J].

Lutz, Jean-Francois ;

Stiller, Sabrina ;

Hoth, Ann ;

Kaufner, Lutz ;

Pison, Ulrich ;

Cartier, Regis .

BIOMACROMOLECULES, 2006, 7 (11) :3132-3138

[36] Preparation and characterization of magnetite nanoparticles coated by amino silane [J].

Ma, M ;

Zhang, Y ;

Yu, W ;

Shen, HY ;

Zhang, HQ ;

Gu, N .

COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 2003, 212 (2-3) :219-226

[37] Study on the endocytosis and the internalization mechanism of aminosilane-coated Fe3O4 nanoparticles in vitro [J].

Ma, Yong-Jie ;

Gu, Hong-Chen .

JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, 2007, 18 (11) :2145-2149

[38]

McBain SC, 2008, INT J NANOMED, V3, P169

[39] Completely dispersible PEGylated gold nanoparticles under physiological conditions: Modification of gold nanoparticles with precisely controlled PEG-b-polyamine [J].

Miyamoto, Daisuke ;

Oishi, Motoi ;

Kojima, Keiji ;

Yoshimoto, Keitaro ;

Nagasaki, Yukio .

LANGMUIR, 2008, 24 (09) :5010-5017

[40] Stealth liposomes and long circulating nanoparticles: critical issues in pharmacokinetics, opsonization and protein-binding properties [J].

Moghimi, SM ;

Szebeni, J .

PROGRESS IN LIPID RESEARCH, 2003, 42 (06) :463-478

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