Functionalization of inorganic nanoparticles with polymers for stealth biomedical applications

被引：80

作者：

Neoh, Koon Gee ^{[1
]}

Kang, En Tang ^{[1
]}

机构：

[1] Natl Univ Singapore, Dept Chem & Biomol Engn, Kent Ridge 119260, Singapore

来源：

POLYMER CHEMISTRY | 2011年 / 2卷 / 04期

关键词：

IRON-OXIDE NANOPARTICLES; SURFACE-INITIATED POLYMERIZATION; TRANSFER RADICAL POLYMERIZATION; PEGYLATED GOLD NANOPARTICLES; SELF-ASSEMBLED MONOLAYERS; DRUG-DELIVERY SYSTEMS; MAGNETITE NANOPARTICLES; FE3O4; NANOPARTICLES; POLY(ETHYLENE GLYCOL); IN-VITRO;

D O I：

10.1039/c0py00266f

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Inorganic nanoparticles offer great opportunities in biomedicine, for example, serving as contrast agents for imaging, hyperthermia agents and drug delivery vehicles. A critical factor limiting the applications of nanoparticles for therapeutic and diagnostic purposes is their short circulation time in vivo due to clearance by the body's reticuloendothelial system. One of the most efficient strategies to confer stealthiness to nanoparticles is the use of a polymer "cloak" which inhibits plasma protein adsorption and recognition by the immune system. This review describes some of the polymers which are suitable for these applications, and the strategies which can be employed to functionalize inorganic nanoparticles with such polymers.

引用

页码：747 / 759

页数：13

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