Kisspeptin in the medial amygdala and sexual behavior in male rats

被引：58

作者：

Gresham, Rebecca ^{[1
]}

Li, Shengyun ^{[1
]}

Adekunbi, Daniel A. ^{[1
]}

Hu, Minghan ^{[1
]}

Li, Xiao Feng ^{[1
]}

O'Byrne, Kevin T. ^{[1
]}

机构：

[1] Kings Coll London, Fac Life Sci & Med, Div Womens Hlth, 2-92W,Hodgkin Bldg,Guys Campus, London SE1 1UL, England

来源：

NEUROSCIENCE LETTERS | 2016年 / 627卷

基金：

英国生物技术与生命科学研究理事会;

关键词：

Amygdala; Kisspeptin; Erection; Sexual behavior; Male; Rat; STRESS-INDUCED SUPPRESSION; PITUITARY-GONADAL AXIS; PREOPTIC AREA; PENILE ERECTION; HORMONE RELEASE; ESTROUS FEMALES; FOS EXPRESSION; RECEPTOR; DISCOVERY; BRAIN;

D O I：

10.1016/j.neulet.2016.05.042

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The medial amygdala (MeA) is crucial for sexual behavior; kisspeptin (Kiss1) also plays a role in sexual function. Kisspeptin receptor (Kiss1r) knockout mice display no sexual behavior. Recently Kiss1 and Kiss1r have been discovered in the posterodorsal subnucleus of the medial amygdala (MePD). We hypothesised that Kiss1 in the MePD may have an influence on male sexual behavior. To test this we bilaterally cannulated the MePD and infused kisspeptin-10 in male rats. This caused the rats to have multiple erections, an effect specific to Kiss1 receptor activation, because Kiss1r antagonism blocked the erectile response. When Kiss1 was infused into the lateral cerebroventricle, there were no observed erections. We also measured the plasma levels of LH when Kiss1 is infused into the MePD or lateral cerebroventricle; Kiss1 increased plasma LH to comparable levels when infused into both sites. We conclude that Kiss1 has a role in male sexual behavior, which is specific to the MePD. (C) 2016 The Authors. Published by Elsevier Ireland Ltd.

引用

收藏

页码：13 / 17

页数：5

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