A Rationale for Targeting Extracellular Regulated Kinases ERK1 and ERK2 in Glioblastoma

被引：21

作者：

Hannen, Ricarda ^{[1
]}

Hauswald, Maria ^{[1
]}

Bartsch, Joerg Walter ^{[1
]}

机构：

[1] Philipps Univ Marburg UKGM, Dept Neurosurg, Marburg, Germany

来源：

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY | 2017年 / 76卷 / 10期

关键词：

ERK inhibitors; Extracellular regulated kinase; Glioblastoma; ACTIVATED PROTEIN-KINASE; ENDOTHELIAL GROWTH-FACTOR; CELL-PROLIFERATION; GLIOMA-CELLS; IN-VITRO; SUBCELLULAR-LOCALIZATION; SIGNALING PATHWAY; MALIGNANT GLIOMA; OXIDATIVE STRESS; DOWN-REGULATION;

D O I：

10.1093/jnen/nlx076

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Glioblastoma (GBM) is the most common malignant primary brain tumor. It still carries a grim prognosis and new therapies are needed. This review summarizes the current status of mechanistic insights into the function of extracellular regulated kinase (ERK) and its potential as a therapeutic target for patients with GBM. Currently, some promising ERK inhibitors are in clinical trials in tumor entities other than GBM. Here, we provide a comprehensive overview on the functions of ERK1/2 in GBM and a rationale for treatment of GBM with ERK inhibitors.

引用

页码：838 / 847

页数：10

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