COVID-19-related myocarditis and cholinergic anti-inflammatory pathways

被引：5
作者：
Liu, Weike [1 ,2 ]
Liu, Zhendong [3 ]
Li, Yue-Chun [1 ,2 ]
机构：
[1] Wenzhou Med Univ, Affiliated Hosp 2, Dept Cardiol, 109 Xueyuan Rd, Wenzhou 325000, Zhejiang, Peoples R China
[2] Wenzhou Med Univ, Yuying Childrens Hosp, 109 Xueyuan Rd, Wenzhou 325000, Zhejiang, Peoples R China
[3] Shandong First Med Univ, Basic Med Coll, 18877 Jingshi Rd, Jinan 250062, Shandong, Peoples R China
来源：
HELLENIC JOURNAL OF CARDIOLOGY | 2021年 / 62卷 / 04期
基金：
中国国家自然科学基金;
关键词：
Severe acute respiratory syndrome coronavirus-2; Myocarditis; Cholinergic anti-inflammatory pathway; VAGUS NERVE; CONVERTING ENZYME; INFLAMMATORY RESPONSE; VIRAL MYOCARDITIS; ACE2; COMORBIDITIES; PREVALENCE; MODULATION; PHYSIOLOGY; STRATEGY;
D O I：
10.1016/j.hjc.2020.12.004
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Coronavirus disease-2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus-2, is currently in a pandemic outbreak and has become a global health issue. In addition to the primarily involvement of the respiratory system, myocarditis is considered an important and fatal lesion in patients with COVID-19. However, effective therapeutic methods are currently lacking. The cholinergic anti-inflammatory pathway (CAP) has been demonstrated to suppress pro-inflammatory cytokine production and control inflammation in sepsis and other medical conditions. Therefore, the CAP may be a potential and effective therapeutic method for COVID-19-related myocarditis. This article reviews the relationship between COVID-19-related myocarditis and the CAP and discusses the CAP as a potential therapeutic modality in the treatment of COVID-19-related myocarditis. (C) 2020 Hellenic Society of Cardiology. Publishing services by Elsevier B.V.
引用
收藏
页码：265 / 269
页数：5
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