Analysis of Side Effects Following Vaccination Against COVID-19 Among Individuals With Multiple Sclerosis Treated With DMTs in Poland

被引：9

作者：

Czarnowska, Agata ^{[1
]}

Tarasiuk, Joanna ^{[1
]}

Zajkowska, Olga ^{[2
]}

Wnuk, Marcin ^{[3
]}

Marona, Monika ^{[3
]}

Nowak, Klaudia ^{[3
]}

Slowik, Agnieszka ^{[3
]}

Jamroz-Wisniewska, Anna ^{[4
]}

Rejdak, Konrad ^{[4
]}

Lech, Beata ^{[5
]}

Popiel, Malgorzata ^{[5
]}

Rosciszewska-Zukowska, Iwona ^{[6
]}

Perenc, Adam ^{[5
]}

Bartosik-Psujek, Halina ^{[6
]}

Swiderek-Matysiak, Mariola ^{[7
]}

Siger, Malgorzata ^{[7
]}

Ciach, Agnieszka ^{[7
]}

Walczak, Agata ^{[7
]}

Jurewicz, Anna ^{[7
]}

Stasiolek, Mariusz ^{[7
]}

Kania, Karolina ^{[8
]}

Dyczkowska, Klara ^{[8
]}

Kalinowska-Lyszczarz, Alicja ^{[9
]}

Galus, Weronika ^{[10
]}

Walawska-Hrycek, Anna ^{[10
]}

Krzystanek, Ewa ^{[10
]}

Chojdak-Lukasiewicz, Justyna ^{[11
]}

Ubysz, Jakub ^{[11
]}

Pokryszko-Dragan, Anna ^{[11
]}

Kapica-Topczewska, Katarzyna ^{[1
]}

Chorazy, Monika ^{[1
]}

Bazylewicz, Marcin ^{[1
]}

Mironczuk, Anna ^{[1
]}

Kulikowska, Joanna ^{[1
]}

Kochanowicz, Jan ^{[1
]}

Bialek, Marta ^{[12
]}

Stolarz, Malgorzata ^{[12
]}

Kubicka-Baczyk, Katarzyna ^{[13
]}

Niedziela, Natalia ^{[13
]}

Warmus, Pawel ^{[13
]}

Adamczyk-Sowa, Monika ^{[13
]}

Podlecka-Pictowska, Aleksandra ^{[14
]}

Nojszewska, Monika ^{[14
]}

Zakrzewska-Pniewska, Beata ^{[14
]}

Jasinska, Elzbieta ^{[15
,16
]}

Zaborski, Jacek ^{[17
]}

Milewska-Jedrzejczak, Marta ^{[18
]}

Zwiernik, Jacek ^{[19
,20
]}

Zwiernik, Beata ^{[21
,22
]}

Potemkowski, Andrzej ^{[23
]}

机构：

[1] Med Univ Bialystok, Dept Neurol, Bialystok, Poland

[2] Univ Warsaw, Fac Econ Sci, Warsaw, Poland

[3] Jagiellonian Univ Med Coll, Dept Neurol, Krakow, Poland

[4] Med Univ Lublin, Dept Neurol, Lublin, Poland

[5] Clin Hosp 2 Rzeszow, Neurol Clin, Brain Stroke Sub Unit, Lwowska, Poland

[6] Rzeszow Univ, Med Coll, Inst Med Sci, Dept Neurol, Rzeszow, Poland

[7] Med Univ Lodz, Dept Neurol, Lodz, Poland

[8] Poznan Univ Med Sci, Dept Neurol, Poznan, Poland

[9] Poznan Univ Med Sci, Div Neurochem & Neuropathol, Poznan, Poland

[10] Med Univ Silesiaia, Fac Med Sci Katowice, Dept Neurol, Katowice, Poland

[11] Wroclaw Med Univ, Dept Neurol, Wroclaw, Poland

[12] Reg Specialised Hosp 4 Bytom, Dept Neurol, Bytom, Poland

[13] Med Univ Silesiaia Katowice, Fac Med Sci Zabrze, Dept Neurol, Katowice, Poland

[14] Med Univ Warsaw, Dept Neurol, Warsaw, Poland

[15] Jan Kochanowski Univ, Coll Medicum, Kielce, Poland

[16] Resmedica, Clin Ctr, Kielce, Poland

[17] Miedzyleski Szpital Specjalistyczny, Dept Neurol & Neurorehabil, Warsaw, Poland

[18] Med Univ Lodz, Dept Neurol & Ischem Strokes, Lodz, Poland

[19] Prov Specialist Hosp, Neurol Ward, Olsztyn, Poland

[20] Univ Warmia & Mazury, Dept Neurol, Olsztyn, Poland

[21] Univ Warmia & Mazury, Dept Neurol, Olsztyn, Poland

[22] Univ Warmia & Mazury, Clin Neurol, Olsztyn, Poland

[23] Univ Szczecin, Dept Clin Psychol & Psychoprophylaxis, Szczecin, Poland

[24] Jan Kochanowski Univ Kielce, Specialist Hosp Konskie, Dept Neurol, Coll Medicum, Kielce, Poland

来源：

FRONTIERS IN NEUROLOGY | 2022年 / 13卷

关键词：

multiple sclerosis; vaccination; SARS-CoV-2; COVID-19; side effects;

D O I：

10.3389/fneur.2022.913283

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background and ObjectivesSince vaccination against COVID-19 is available for over a year and the population of immunized individuals with autoimmune disorders is higher than several months before, an evaluation of safety and registered adverse events can be made. We conducted a large study of side effects following the COVID-19 vaccine among patients with multiple (MS) sclerosis treated with disease-modifying therapies (DMTs) and analyzed factors predisposing for particular adverse events. MethodsWe gathered data of individuals with MS treated with DMTs from 19 Polish MS Centers, who reported at least one adverse event following COVID-19 vaccination. The information was obtained by neurologists using a questionnaire. The same questionnaire was used at all MS Centers. To assess the relevance of reported adverse events, we used Fisher's exact test, t-test, and U-Menn-Whutney test. ResultsA total of 1,668 patients with MS and reports of adverse events after COVID-19 vaccination were finally included in the study. Besides one case marked as "red flag", all adverse events were classified as mild. Pain at the injection site was the most common adverse event, with a greater frequency after the first dose. Pain at the injection site was significantly more frequent after the first dose among individuals with a lower disability (EDSS <= 2). The reported adverse events following immunization did not differ over sex. According to age, pain at the injection site was more common among individuals between 30 and 40 years old, only after the first vaccination dose. None of the DMTs predisposed for particular side effects. ConclusionsAccording to our findings, vaccination against COVID-19 among patients with MS treated with DMTs is safe. Our study can contribute to reducing hesitancy toward vaccination among patients with MS.

引用

页数：9

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