How statistical deception created the appearance that statins are safe and effective in primary and secondary prevention of cardiovascular disease

被引:43
作者
Diamond, David M. [1 ,2 ,3 ]
Ravnskov, Uffe
机构
[1] Vet Hosp, Med Res Serv, Tampa, FL 33612 USA
[2] Univ S Florida, Dept Psychol, Ctr Preclin & Clin Res PTSD, Tampa, FL 33620 USA
[3] Univ S Florida, Dept Mol Pharmacol & Physiol, Ctr Preclin & Clin Res PTSD, Tampa, FL 33620 USA
关键词
absolute risk; adverse effects; cancer; dementia; hypercholesterolemia; myositis; relative risk; statins; trials; CORONARY-HEART-DISEASE; RANDOMIZED CONTROLLED-TRIAL; DIETARY CARBOHYDRATE RESTRICTION; SATURATED FAT; SERUM-CHOLESTEROL; VASCULAR-DISEASE; PANIC DISORDER; RISK; CANCER; ATHEROSCLEROSIS;
D O I
10.1586/17512433.2015.1012494
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
We have provided a critical assessment of research on the reduction of cholesterol levels by statin treatment to reduce cardiovascular disease. Our opinion is that although statins are effective at reducing cholesterol levels, they have failed to substantially improve cardiovascular outcomes. We have described the deceptive approach statin advocates have deployed to create the appearance that cholesterol reduction results in an impressive reduction in cardiovascular disease outcomes through their use of a statistical tool called relative risk reduction (RRR), a method which amplifies the trivial beneficial effects of statins. We have also described how the directors of the clinical trials have succeeded in minimizing the significance of the numerous adverse effects of statin treatment.
引用
收藏
页码:201 / 210
页数:10
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