Plasma Levels of Glial Cell Marker S100B in Children With Autism

被引：12

作者：

Tomova, A. ^{[1
]}

Kemenyova, P. ^{[1
]}

Filcikova, D. ^{[1
]}

Szapuova, Z. ^{[1
]}

Kovac, A. ^{[2
]}

Babinska, K. ^{[1
]}

Ostatnikova, D. ^{[1
]}

机构：

[1] Comenius Univ, Fac Med, Inst Physiol, Sasinkova 2, Bratislava 81372, Slovakia

[2] Slovak Acad Sci, Inst Neuroimmunol, Bratislava, Slovakia

来源：

PHYSIOLOGICAL RESEARCH | 2019年 / 68卷

关键词：

S100B; Autism; Serotonin; BLOOD SEROTONIN LEVELS; FECAL CALPROTECTIN; SPECTRUM DISORDER; DIAGNOSTIC INTERVIEW; PROTEIN; BIOMARKER; INDIVIDUALS; MICROBIOTA;

D O I：

10.33549/physiolres.934350

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Autism spectrum disorder (ASD) is a neurodevelopmental condition with increasing incidence. Recent evidences suggest glial cells involvement in autism pathophysiology. S100B is a calcium binding protein, mainly found in astrocytes and therefore used as a marker of their activity. In our study, children with autism had higher plasma concentrations of S100B compared to non-autistic controls. No association of S100B plasma levels with behavioral symptoms (ADI-R and ADOS-2 scales) was found. Plasma S100B concentration significantly correlated with urine serotonin, suggesting their interconnection. Correlation of plasma S100B levels with stool calprotectin concentrations was found, suggesting not only brain astrocytes, but also enteric glial cells may take part in autism pathogenesis. Based on our findings, S100B seems to have a potential to be used as a biomarker of human neurodevelopmental disorders, but more investigations are needed to clarify its exact role in pathomechanism of autism.

引用

页码：S315 / S323

页数：9

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