Exercise-Associated Iron Deficiency: A Review and Recommendations for Practice

被引：6
作者：
Goldstein, Erica R. [1 ]
机构：
[1] Mayo Clin, Jacksonville, FL 32224 USA
来源：
STRENGTH AND CONDITIONING JOURNAL | 2016年 / 38卷 / 02期
关键词：
red blood cells; hemolysis; iron deficiency; iron; hepcidin; inflammation; anemia; PLACEBO-CONTROLLED TRIAL; FEMALE SOLDIERS; SERUM FERRITIN; DOUBLE-BLIND; HEPCIDIN; SUPPLEMENTATION; INTERLEUKIN-6; PERFORMANCE; METABOLISM; ENDURANCE;
D O I：
10.1519/SSC.0000000000000202
中图分类号：
G8 [体育];
学科分类号：
04 ; 0403 ;
摘要：
IRON DEFICIENCY IS PREVALENT IN FEMALE ATHLETES AND CAN IMPEDE ENDURANCE PERFORMANCE (I.E., SLOWER TIME TRIAL), AND WITH ANEMIA CAN REDUCE ENDURANCE CAPACITY. LEVELS OF HEPCIDIN ARE ELEVATED AFTER EXERCISE SECOND TO INFLAMMATORY STIMULI (INTERLEUKIN-6) AND MAY CONTRIBUTE TO THE DEVELOPMENT OF IRON DEFICIENCY. HEPCIDIN ACTS TO INTERNALIZE AND DEGRADE FERROPORTIN (CELLULAR CHANNEL RESPONSIBLE FOR IRON EFFLUX). THIS RESULTS IN SEQUESTRATION OF IRON WITHIN MACROPHAGES, WHICH RECYCLE IRON FROM AGED AND DAMAGED ERYTHROCYTES. PROLONGED HIGH-INTENSITY TRAINING, ESPECIALLY A MODALITY THAT INCLUDES REPETITIVE FOOT STRIKES, CAN CAUSE HEMOLYSIS RESULTING IN UPREGULATION OF HEPCIDIN AND MAY CONTRIBUTE TO THE DEVELOPMENT OF IRON DEFICIENCY.
引用
收藏
页码：24 / 34
页数：11
相关论文
共 51 条
[11]  
Fischer CP, 2006, EXERC IMMUNOL REV, V12, P6
[12]   Endurance training reduces the contraction-induced interleukin-6 mRNA expression in human skeletal muscle [J].
Fischer, CP ;
Plomgaard, P ;
Hansen, AK ;
Pilegaard, H ;
Saltin, B ;
Pedersen, BK .
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2004, 287 (06) :E1189-E1194
[13]   Iron deficiency anemia in celiac disease [J].
Freeman, Hugh James .
WORLD JOURNAL OF GASTROENTEROLOGY, 2015, 21 (31) :9233-9238
[14]   Molecular control of iron transport [J].
Ganz, Tomas .
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2007, 18 (02) :394-400
[15]   Effect of iron-fortified foods on hematologic and biological outcomes: systematic review of randomized controlled trials [J].
Gera, Tarun ;
Sachdev, Harshpal Singh ;
Boy, Erick .
AMERICAN JOURNAL OF CLINICAL NUTRITION, 2012, 96 (02) :309-324
[16]  
Gropper S.S., 2009, Advanced Nutrition and Human Metabolism, P469
[17]   Impact of menstrual blood loss and diet on iron deficiency among women in the UK [J].
Harvey, LJ ;
Armah, CN ;
Dainty, JR ;
Foxall, RJ ;
Lewis, DJ ;
Langford, NJ ;
Fairweather-Tait, SJ .
BRITISH JOURNAL OF NUTRITION, 2005, 94 (04) :557-564
[18]   Iron supplementation improves endurance after training in iron-depleted, nonanemic women [J].
Hinton, PS ;
Giordano, C ;
Brownlie, T ;
Haas, JD .
JOURNAL OF APPLIED PHYSIOLOGY, 2000, 88 (03) :1103-1111
[19]  
*I MED FOOD NUTR B, 2001, DIET REF INT VIT A A
[20]   Randomized, double-blind, placebo-controlled trial of an iron-fortified food product in female soldiers during military training: relations between iron status, serum hepcidin, and inflammation [J].
Karl, J. Philip ;
Lieberman, Harris R. ;
Cable, Sonya J. ;
Williams, Kelly W. ;
Young, Andrew J. ;
McClung, James P. .
AMERICAN JOURNAL OF CLINICAL NUTRITION, 2010, 92 (01) :93-100
123456