Water dispersible pH-responsive chitosan nanogels modified with biocompatible crosslinking-agents

被引：59
作者：
Arteche Pujana, Maite [1 ]
Perez-Alvarez, Leyre [1 ]
Cesteros Iturbe, L. Carlos [1 ]
Katime, Issa [1 ]
机构：
[1] Univ Pais Vasco UPV EHU, Fac Ciencia & Tecnol, Dept Quim Fis, Grp Nuevos Mat & Espect Supramol, Bilbao 644, Spain
来源：
POLYMER | 2012年 / 53卷 / 15期
关键词：
Chitosan; Nanogel; pH-responsive; LIGHT-SCATTERING; LINKED CHITOSAN; DRUG-DELIVERY; POLYMER NETWORKS; IN-VITRO; NANOPARTICLES; MICROEMULSION; ACETYLATION; CHITIN; MICROSPHERES;
D O I：
10.1016/j.polymer.2012.05.027
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
Chitosan nanoparticles were obtained by crosslinking with two biocompatible dicarboxylic acids: polyethylene glycol dicarboxylic acid and tartaric acid. The water-in-oil (W/O) microemulsion method yielded particle sizes around 10-15 nm in the dried state (TEM) and 200-700 nm in the swollen state (QELS) from commercial chitosan. All the synthesized nanogels showed improved water solubility and most of them were stable at physiological pH. QELS studies revealed the influence of the hydrophilic character and flexibility of the crosslinker on the swelling behaviour of the nanogels. The nanoparticles showed a pH-sensitive volume transition that was consistent with the pKa of chitosan. The collected zeta potential data corroborated the electrostatic repulsion mechanism responsible for the pH-responsive behaviour. (C) 2012 Elsevier Ltd. All rights reserved.
引用
收藏
页码：3107 / 3116
页数：10
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