Radon carcinogenesis: Risk data and cellular hits

被引：9

作者：

Harley, Naomi H. ^{[1
]}

Chittaporn, Passaporn ^{[1
]}

Heikkinen, Maire S. A. ^{[1
]}

Meyers, Owen A. ^{[3
]}

Robbins, Edith S. ^{[2
,3
]}

机构：

[1] NYU, Sch Med, Dept Environm Med, New York, NY 10016 USA

[2] NYU, Sch Med, Dept Cell Biol, New York, NY 10016 USA

[3] CUNY, Borough Manhattan Community Coll, New York, NY 10007 USA

来源：

RADIATION PROTECTION DOSIMETRY | 2008年 / 130卷 / 01期

关键词：

D O I：

10.1093/rpd/ncn123

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Abundant epidemiological data are now available (2008) on the human lung cancer response for lifetime radon gas exposure to residential concentrations of 100 Bq m(-3), equal to 22 working level months over 40 y. We combined published pooled epidemiological data and dosimetric calculations of alpha particle hits to target basal or mucous cell nuclei in bronchial epithelium. This yields an estimate that about 10 000 basal nuclei (target) cell hits per cm(2) per person over a lifetime are involved in radon-related lung cancer. The DNA target cell area (cross section) for a hit is about 2 bp. The present epidemiology indicates that 1000 persons need to be exposed to this hit rate for observable cancers to be detected. The mechanism proposed is that the extensive prior DNA damage in smokers, followed by alpha particle damage to a critical site in checkpoint genes, accounts for the greater lung cancer response in smokers.

引用

页码：107 / 109

页数：3