Nukiangendines A and B, two novel 13,14-seco-abietanes from Abies nukiangensis

被引：6

作者：

Li, Yong-Li ^{[1
]}

Zhang, Qiang ^{[2
]}

Wu, Jian-Jun ^{[1
]}

Xue, Li-Jun ^{[3
]}

Chen, Li-Ming ^{[1
]}

Tian, Jun-Mian ^{[2
]}

Xu, Zhuo-Ni ^{[1
]}

Chen, Ying ^{[1
]}

Yang, Xian-Wen ^{[4
]}

Hao, Xiao-Jiang ^{[5
]}

Li, Jie ^{[1
]}

机构：

[1] Shanghai Inst Measurement & Testing Technol, Phys & Chem Anal Lab, Div Mat Sci & Qual Test, 1500 Zhangheng Rd, Shanghai 201203, Peoples R China

[2] Northwest A&F Univ, Shaanxi Key Lab Nat Prod & Chem Biol, Coll Sci, 3 Taicheng Rd, Yangling 712100, Shaanxi, Peoples R China

[3] Nanjing Univ, Dept Med Oncol, Jinling Hosp, Clin Sch Med, 305 East Zhongshan Rd, Nanjing 210002, Jiangsu, Peoples R China

[4] Minist Nat Resources, Key Lab Marine Biogenet Resources, Inst Oceanog 3, 184 Daxue Rd, Xiamen 361005, Peoples R China

[5] Chinese Acad Sci, State Key Lab Phytochem & Plant Resources West Ch, Kunming Inst Bot, Kunming 650201, Yunnan, Peoples R China

来源：

TETRAHEDRON LETTERS | 2019年 / 60卷 / 10期

基金：

中国国家自然科学基金;

关键词：

Abies nukiangensis; seco-Abietane; Diterpene; Antiviral; DITERPENOIDS; TRUNK;

D O I：

10.1016/j.tetlet.2019.02.008

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

From Abies nukiangensis, two novel 13,14-seco-abietane diterpenes, nukiangendines A (1) and B (2) were isolated. Their relative structures were determined by extensive NMR and HAMS spectroscopic analysis. The absolute configuration of 1 was established by ECD calculations. Compound 1 showed significant anti-hepatitis C virus (HCV) effects. (C) 2019 Elsevier Ltd. All rights reserved.

引用

页码：751 / 753

页数：3

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