Association between mitochondrial DNA 10398A>G polymorphism and the volume of amygdala

被引：10
作者：
Yamasue, H. [1 ,2 ]
Kakiuchi, C. [2 ]
Tochigi, M. [1 ,2 ]
Inoue, H. [1 ]
Suga, M. [1 ]
Abe, O. [3 ]
Yamada, H. [3 ]
Sasaki, T. [1 ]
Rogers, M. A. [1 ]
Aoki, S. [3 ]
Kato, T. [2 ]
Kasai, K. [1 ]
机构：
[1] Univ Tokyo, Grad Sch Med, Dept Neuropsychiat, Bunkyo Ku, Tokyo 1138655, Japan
[2] RIKEN, Brain Sci Inst, Lab Mol Dynam Mental Disorders, Wako, Saitama, Japan
[3] Univ Tokyo, Grad Sch Med, Dept Radiol, Tokyo 1138655, Japan
来源：
GENES BRAIN AND BEHAVIOR | 2008年 / 7卷 / 06期
关键词：
amygdala; bipolar disorder; endophenotype; mitochondria; MRI; volumetry; voxel-based morphometry;
D O I：
10.1111/j.1601-183X.2008.00408.x
中图分类号：
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号：
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要：
Mitochondrial calcium regulation plays a number of important roles in neurons. Mitochondrial DNA (mtDNA) is highly polymorphic, and its interindividual variation is associated with various neuropsychiatric diseases and mental functions. An mtDNA polymorphism, 10398A > G, was reported to affect mitochondrial calcium regulation. Volume of hippocampus and amygdala is reportedly associated with various mental disorders and mental functions and is regarded as an endophenotype of mental disorders. The present study investigated the relationship between the mtDNA 10398A > G polymorphism and the volume of hippocampus and amygdala in 118 right-handed healthy subjects. The brain morphometry using magnetic resonance images employed both manual tracing volumetry in the native space and voxel-based morphometry (VBM) in the spatially normalized space. Amygdala volume was found to be significantly larger in healthy subjects with 10398A than in those with 10398G by manual tracing, which was confirmed by the VBM. Brain volumes in the other gray matter regions and all white matter regions showed no significant differences associated with the polymorphism. These provocative findings might provide a clue to the complex relationship between mtDNA, brain structure and mental disorders.
引用
收藏
页码：698 / 704
页数：7
相关论文
共 59 条
[1]   Amygdala enlargement in bipolar disorder and hippocampal reduction in schizophrenia: An MRI study demonstrating neuroanatomic specificity [J].
Altshuler, LL ;
Bartzokis, G ;
Grieder, T ;
Curran, J ;
Mintz, J .
ARCHIVES OF GENERAL PSYCHIATRY, 1998, 55 (07) :663-664
[2]   Correlates of intellectual ability with morphology of the hippocampus and amygdala in healthy adults [J].
Amat, Jose A. ;
Bansal, Ravi ;
Whiteman, Ronald ;
Haggerty, Rita ;
Royal, Jason ;
Peterson, Bradley S. .
BRAIN AND COGNITION, 2008, 66 (02) :105-114
[3]   Voxel-based morphometry - The methods [J].
Ashburner, J ;
Friston, KJ .
NEUROIMAGE, 2000, 11 (06) :805-821
[4]   Volumetric brain imaging findings in mood disorders [J].
Beyer, JL ;
Krishnan, KRR .
BIPOLAR DISORDERS, 2002, 4 (02) :89-104
[5]   Voxel-based morphometry should not be used with imperfectly registered images [J].
Bookstein, FL .
NEUROIMAGE, 2001, 14 (06) :1454-1462
[6]  
Bremner J Douglas, 2006, Dialogues Clin Neurosci, V8, P445
[7]   The human amygdala: a systematic review and meta-analysis of volumetric magnetic resonance imaging [J].
Brierley, B ;
Shaw, P ;
David, AS .
BRAIN RESEARCH REVIEWS, 2002, 39 (01) :84-105
[8]  
Campanella M, 2004, BIOL RES, V37, P653
[9]   Mitochondrial DNA G10398A polymorphism and invasive breast cancer in African-American women [J].
Canter, JA ;
Kallianpur, AR ;
Parl, FF ;
Millikan, RC .
CANCER RESEARCH, 2005, 65 (17) :8028-8033
[10]   Mitochondrial DNA G10398A polymorphism imparts maternal Haplogroup N a risk for breast and esophageal cancer [J].
Darvishi, Katayoon ;
Sharma, Swarkar ;
Bhat, Audesh K. ;
Rai, Ekta ;
Bamezai, R. N. K. .
CANCER LETTERS, 2007, 249 (02) :249-255
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