The novel antifungal agent AB-22 displays in vitro activity against hyphal growth and biofilm formation in Candida albicans and potency for treating systemic candidiasis

被引:3
作者
Lee, Kyung-Tae [1 ]
Lee, Dong-Gi [2 ]
Choi, Ji Won [3 ,4 ]
Park, Jong-Hyun [3 ,4 ]
Park, Ki Duk [3 ,4 ]
Lee, Jong-Seung [2 ]
Bahn, Yong-Sun [1 ]
机构
[1] Yonsei Univ, Coll Life Sci & Biotechnol, Dept Biotechnol, Seoul 03722, South Korea
[2] AmtixBio Co Ltd, Hanam 12925, South Korea
[3] Korea Inst Sci & Technol KIST, Brain Sci Inst, Seoul 02792, South Korea
[4] Korea Univ Sci & Technol, KIST Sch, Div Biomed Sci & Technol, Seoul 02792, South Korea
关键词
systemic candidiasis; biofilm; antifungal drug efficacy; INVASIVE CANDIDIASIS; RESISTANCE;
D O I
10.1007/s12275-022-2016-0
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Systemic candidiasis, which is mainly caused by Candida albicans, is a serious acute fungal infection in the clinical setting. In a previous study, we reported that compound 22h (designated as AB-22 in this study), a vinyl sulfate compound, is a fast-acting fungicidal agent against a broad spectrum of fungal pathogens. In this study, we aimed to further analyze the in vitro and in vivo efficacy of AB-22 against filamentation, biofilm formation, and virulence of C. albicans. Under in vitro hyphal growth-inducing condition, AB-22 effectively inhibited germ tube formation and hyphal growth, which are required for the initiation of biofilm formation. Indeed, AB-22 significantly suppressed C. albicans biofilm formation in a dose-dependent manner. Moreover, AB-22 treatment inhibited the normal induction of ALS3, HWP1, and ECE1, which are all required for hyphal transition in C. albicans. Furthermore, AB-22 treatment increased the survival of mice systemically infected with C. albicans. In conclusion, in addition to its fungicidal activity, AB-22 inhibits filamentation and biofilm formation in C. albicans, which could collectively contribute to its potent in vivo efficacy against systemic candidiasis.
引用
收藏
页码:438 / 443
页数:6
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