Morphometric changes induced by amino acid supplementation in skeletal and cardiac muscles of old mice

被引:60
作者
Corsetti, Giovanni [1 ]
Pasini, Evasio [2 ]
D'Antona, Giuseppe [3 ,4 ]
Nisoli, Enzo [5 ]
Flati, Vincerlzo [6 ]
Assanelli, Deodato [7 ]
Dioguardi, Francesco S. [8 ]
Bianchi, Rossella [1 ]
机构
[1] Univ Brescia, Div Human Anat, Dept Biomed Sci & Biotechnol, I-25124 Brescia, Italy
[2] Fdn Salvatore Maugeri, IRCCS, Sci Inst Lumezzane, Brescia, Italy
[3] Univ Pavia, Dept Expt Med, Human Physiol Unit, I-27100 Pavia, Italy
[4] Univ Pavia, Interuniv Inst Myol, I-27100 Pavia, Italy
[5] Univ Milan, Dept Pharmacol Chemotherapy & Med Toxicol, Milan, Italy
[6] Univ Aquila, Dept Expt Med, I-67100 Laquila, Italy
[7] Univ Brescia, Dept Sports Med, Brescia, Italy
[8] Univ Milan, Dept Internal Med, Milan, Italy
关键词
D O I
10.1016/j.amjcard.2008.02.078
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Aging is associated with progressive structural disorganization of muscular and cardiac fibers, decreasing functional capacity, and increased rates of disease and death. Aging is also characterized by disturbances in protein synthesis with impaired cellular organelle functions, particularly in the mitochondria. The availability of amino acids is a key factor for the overall metabolism of mammals and exogenous supplements of amino acid mixtures (AAm) could be a valid therapeutic strategy to improve quality of life, avoiding malnutrition and, muscle wasting in the elderly. We investigated the morphoquantitative effects of long-term AAm supplementation on the mitochondria and sarcomeres (by electron microscope) and on collagen matrix deposition (by histologic techniques) in both skeletal and cardiac muscles of young and aged mice. Our data showed that old animals have fewer mitochondria and massive fibrosis in both muscles. Long-term AAm supplementation increased the number and volume of mitochondria and sarcomeres and decreased fibrosis in both skeletal muscle and hearts in old rats. These findings indicate that AAm restored muscular morphologic parameters and probably improved the mechanical performance of these organs. (c) 2008 Elsevier Inc. All rights reserved.
引用
收藏
页码:26E / 34E
页数:9
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