B and T cell imbalances in CSF of patients with Hu-antibody associated PNS

被引：23

作者：

de Graaf, Marieke ^{[1
,2
]}

de Beukelaar, Janet ^{[1
,2
]}

Bergsma, Jelmer ^{[3
]}

Kraan, Jaco ^{[1
]}

van den Bent, Martin ^{[2
]}

Klimek, Markus ^{[3
]}

van Norden, Yvette ^{[4
]}

Kusuma, Arinardi ^{[3
]}

Smitt, Peter Sillevis ^{[2
]}

Gratama, Jan Willem ^{[1
]}

机构：

[1] Erasmus Univ, Med Ctr, Dept Med Oncol, NL-3075 EA Rotterdam, Netherlands

[2] Erasmus Univ, Med Ctr, Dept Neurol, NL-3075 EA Rotterdam, Netherlands

[3] Erasmus Univ, Med Ctr, Dept Anaesthesiol, NL-3075 EA Rotterdam, Netherlands

[4] Erasmus Univ, Med Ctr, Dept Trials & Stat, NL-3075 EA Rotterdam, Netherlands

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2008年 / 195卷 / 1-2期

关键词：

paraneoplastic neurological syndromes; Hu-antibody; lymphocyte subsets; cerebrospinal fluid; cancer;

D O I：

10.1016/j.jneuroim.2008.01.007

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In paraneoplastic neurological syndromes associated with Hu-antibodies (Hu-PNS) an important role for cellular immunity is hypothesized. We characterized the cerebrospinal fluid (CSF) pleocytosis in Hu-PNS patients by assessing the major lymphocyte subsets by flow cytometry. The B cell subset in the CSF of Hu-PNS patients showed a significant absolute (similar to 20x) and relative (similar to 3x) expansion, while the numbers of CD4+ T cells, CD8+ T cells and NK cells only showed an absolute expansion (similar to 4-7x) compared to the controls. On the other hand, the NKT cell subset showed a significant relative reduction in CSF and in blood of Hu-PNS patients. The relative B cell expansion is consistent with the intrathecal synthesis of Hu-antibodies, while the increased number of T and NK cells supports an additional role for cellular immunity in the pathogenesis of Hu-PNS. In addition, the autoimmune hypothesis of Hu-PNS is supported by the relative NKT cell deficiency. (C) 2008 Elsevier B.V. All rights reserved.

引用

页码：164 / 170

页数：7

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