Pd-Catalyzed Tandem Cyclization via C-H Arylation and Acylation for the Construction of Polycyclic Scaffolds

被引：33

作者：

Mu, Bing ^{[1
,2
,3
]}

Li, Jingya ^{[4
]}

Zou, Dapeng ^{[1
]}

Wu, Yusheng ^{[1
,4
]}

Chang, Junbiao ^{[1
]}

Wu, Yangjie ^{[1
]}

机构：

[1] Zhengzhou Univ, Coll Chem & Mol Engn, Zhengzhou 450052, Peoples R China

[2] Zhengzhou Normal Univ, Coll Chem & Chem Engn, Zhengzhou 450044, Peoples R China

[3] Huanghe Sci & Technol Coll, Sch Med, Zhengzhou 450000, Peoples R China

[4] Tetranov Biopharm LLC, Zhengzhou 450052, Peoples R China

来源：

ORGANIC LETTERS | 2016年 / 18卷 / 20期

关键词：

DIRECT ACCESS; FUNCTIONALIZATION; ALKYNES; RHODIUM; DERIVATIVES; ANNULATION; ANALOGS; ARYL; ACTIVATION; ALDEHYDES;

D O I：

10.1021/acs.orglett.6b02571

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The first Pd-catalyzed tandem cyclization of imidazo[1,2-a]pyridines with 2-chlorobenzaldehydes through C-H arylation and acylation is presented for the efficient synthesis of novel 6H-benzo[b]imidazo[5,1,2-de]quinolizin-6-ones. The direct acylation reaction proceeded smoothly without the aid of directing groups and in the presence of air as a clean and free terminal oxidant.

引用

页码：5260 / 5263

页数：4

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