Integration of gene expression and brain-wide connectivity reveals the multiscale organization of mouse hippocampal networks

被引：141

作者：

Bienkowski, Michael S. ^{[1
]}

Bowman, Ian ^{[1
]}

Song, Monica Y. ^{[1
]}

Gou, Lin ^{[1
]}

Ard, Tyler ^{[1
]}

Cotter, Kaelan ^{[1
]}

Zhu, Muye ^{[1
]}

Benavidez, Nora L. ^{[1
]}

Yamashita, Seita ^{[1
]}

Abu-Jaber, Jaspar ^{[1
]}

Azam, Sana ^{[1
]}

Lo, Darrick ^{[1
]}

Foster, Nicholas N. ^{[1
]}

Hintiryan, Houri ^{[1
]}

Dong, Hong-Wei ^{[1
,2
,3
,4
]}

机构：

[1] Univ Southern Calif, Keck Sch Med, Ctr Integrated Connect, Stevens Neuroimaging & Informat Inst, Los Angeles, CA 90007 USA

[2] Univ Southern Calif, Dept Neurol, Keck Sch Med, Los Angeles, CA 90007 USA

[3] Univ Southern Calif, Keck Sch Med, Dept Physiol & Neurosci, Los Angeles, CA 90007 USA

[4] Univ Southern Calif, Keck Sch Med, Zilkha Neurogenet Inst, Los Angeles, CA 90007 USA

来源：

NATURE NEUROSCIENCE | 2018年 / 21卷 / 11期

关键词：

PARAVENTRICULAR NUCLEUS; SPATIAL-ORGANIZATION; FUNCTIONAL DOMAINS; SINGLE CELLS; CORTEX; SUBICULUM; DIRECTION; CIRCUITS; ANTERIOR; ANATOMY;

D O I：

10.1038/s41593-018-0241-y

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Understanding the organization of the hippocampus is fundamental to understanding brain function related to learning, memory, emotions, and diseases such as Alzheimer's disease. Physiological studies in humans and rodents have suggested that there is both structural and functional heterogeneity along the longitudinal axis of the hippocampus. However, the recent discovery of discrete gene expression domains in the mouse hippocampus has provided the opportunity to re-evaluate hippocampal connectivity. To integrate mouse hippocampal gene expression and connectivity, we mapped the distribution of distinct gene expression patterns in mouse hippocampus and subiculum to create the Hippocampus Gene Expression Atlas (HGEA). Notably, previously unknown subiculum gene expression patterns revealed a hidden laminar organization. Guided by the HGEA, we constructed the most detailed hippocampal connectome available using Mouse Connectome Project (http://www.mouseconnectome.org) tract tracing data. Our results define the hippocampus' multiscale network organization and elucidate each subnetwork's unique brain-wide connectivity patterns.

引用

页码：1628 / +

页数：23

共 59 条

[1]

Amaral D G, 1993, Curr Opin Neurobiol, V3, P225, DOI 10.1016/0959-4388(93)90214-J

[2]

[Anonymous], MATPLOTLIB MATPLOTLI, DOI [10.5281/zenodo.248351, DOI 10.5281/ZENODO.248351]

[3] Multi-scale brain networks [J].