Comparison of the Cardioprotective Effect of Deoxygenated Hemoglobin-based Oxygen Carrier (HBOC) Pretreatment and Ischemia Preconditioning

被引：3
作者：
You, Zhen [1 ]
Li, Tao [2 ]
Yang, Chengmin [3 ]
Wu, Hong [1 ]
Zeng, Yong [1 ]
机构：
[1] Sichuan Univ, W China Hosp, Dept Hepatobiliopancreatol, Chengdu 610041, Peoples R China
[2] Sichuan Univ, W China Hosp, Lab Anesthesiol & Crit Care Med, Chengdu 610041, Peoples R China
[3] Inst Tianjin Union Biotechnol Dev, Tianjin, Peoples R China
来源：
ARTIFICIAL CELLS BLOOD SUBSTITUTES AND BIOTECHNOLOGY | 2011年 / 39卷 / 01期
关键词：
hemoglobin-based oxygen carrier; pretreatment; ischemia preconditioning; ischemia/reperfusion injury; MYOCARDIAL-ISCHEMIA; REPERFUSION INJURY;
D O I：
10.3109/10731199.2010.495037
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
This study was designed to compare the influence of deoxygenated hemoglobin-based oxygen carrier (HBOC) pretreatment and ischemia preconditioning on cardiac ischemia/reperfusion (I/R) injury. Langendorff-perfused rat hearts were pretreated with 0.1 gHb/dL deoxygenated HBOC or ischemia, then subjected to 50-min warm ischemia and 2-hr reperfusion. The results indicated that deoxygenated HBOC pretreatment and ischemia preconditioning both equally improved the recovery of cardiac function, and reduced the cardiac enzyme release and myocardial histopathological changes as compared to the control group. Therefore our study demonstrated that deoxygenated HBOC pretreatment and ischemia precondition provided equivalent protection to the isolated heart against I/R injury.
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收藏
页码：7 / 11
页数：5
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