Marine Polysaccharides in Pharmaceutical Applications: Fucoidan and Chitosan as Key Players in the Drug Delivery Match Field

被引：111

作者：

Barbosa, Ana Isabel ^{[1
]}

Coutinho, Ana Joyce ^{[1
]}

Costa Lima, Sofia A. ^{[1
]}

Reis, Salette ^{[1
]}

机构：

[1] Univ Porto, Dept Ciencias Quim, LAQV, REQUIMTE,Fac Farm, Rua de Jorge Viterbo Ferreira 228, P-4050313 Porto, Portugal

来源：

MARINE DRUGS | 2019年 / 17卷 / 12期

关键词：

anticancer compounds; nanoparticles; ionic crosslinking method; polyphenolic compounds; polyelectrolyte self-assembly method; VITRO ANTIOXIDANT PROPERTIES; MOLECULAR-WEIGHT FUCOIDAN; COMBINED PHASE-I; SULFATED POLYSACCHARIDES; ANTITUMOR-ACTIVITY; FUCUS-EVANESCENS; NATURAL-PRODUCTS; ORAL DELIVERY; CHITOSAN/FUCOIDAN NANOPARTICLES; STRUCTURAL CHARACTERISTICS;

D O I：

10.3390/md17120654

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The use of marine-origin polysaccharides has increased in recent research because they are abundant, cheap, biocompatible, and biodegradable. These features motivate their application in nanotechnology as drug delivery systems; in tissue engineering, cancer therapy, or wound dressing; in biosensors; and even water treatment. Given the physicochemical and bioactive properties of fucoidan and chitosan, a wide range of nanostructures has been developed with these polysaccharides per se and in combination. This review provides an outline of these marine polysaccharides, including their sources, chemical structure, biological properties, and nanomedicine applications; their combination as nanoparticles with descriptions of the most commonly used production methods; and their physicochemical and biological properties applied to the design of nanoparticles to deliver several classes of compounds. A final section gives a brief overview of some biomedical applications of fucoidan and chitosan for tissue engineering and wound healing.

引用

页数：21

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