18F-6-Fluoro-L-Dopa PET/CT Imaging of Congenital Hyperinsulinism

被引：11
作者：
States, Lisa J. [1 ,2 ,3 ]
Davis, J. Christopher [1 ,2 ,3 ]
Hamel, Steven M. [1 ]
Becker, Susan A. [1 ]
Zhuang, Hongming [1 ,2 ,3 ]
机构：
[1] Childrens Hosp Philadelphia, Radiol Dept, Philadelphia, PA 19104 USA
[2] Univ Penn, Perelman Sch Med, Philadelphia, PA 19104 USA
[3] Childrens Hosp Philadelphia, Philadelphia, PA 19104 USA
来源：
JOURNAL OF NUCLEAR MEDICINE | 2021年 / 62卷
关键词：
F-18-FDOPA; hyperinsulinism; congenital hyperinsulinism; POSITRON-EMISSION-TOMOGRAPHY; COMPUTED TOMOGRAPHY; DOPA DECARBOXYLASE; FOCAL FORM; DIAGNOSIS; INFANCY; ACCURACY; SCAN; LOCALIZATION; HYPOGLYCEMIA;
D O I：
10.2967/jnumed.120.246033
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 ; 100207 ; 1009 ;
摘要：
Congenital hyperinsulinism is characterized by persistent hypoglycemia due to inappropriate excess secretion of insulin resulting in hyper-insulinemic hypoglycemia. The clinical course varies from mild to severe, with a significant risk for brain damage. Imaging plays a valuable role in the care of infants and children with severe hypoglycemia unresponsive to medical therapy. F-18-6-fluoro-L-dopa PET/CT is the method of choice for the detection and localization of a focal lesion of hyperinsulinism. Surgical resection of a focal lesion can lead to a cure with limited pancreatectomy. This article reviews the role of F-18-6-fluoro-L-dopa PET/CT in the management of this vulnerable population.
引用
收藏
页码：51S / 56S
页数：6
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