18F-6-Fluoro-L-Dopa PET/CT Imaging of Congenital Hyperinsulinism

被引：11

作者：

States, Lisa J. ^{[1
,2
,3
]}

Davis, J. Christopher ^{[1
,2
,3
]}

Hamel, Steven M. ^{[1
]}

Becker, Susan A. ^{[1
]}

Zhuang, Hongming ^{[1
,2
,3
]}

机构：

[1] Childrens Hosp Philadelphia, Radiol Dept, Philadelphia, PA 19104 USA

[2] Univ Penn, Perelman Sch Med, Philadelphia, PA 19104 USA

[3] Childrens Hosp Philadelphia, Philadelphia, PA 19104 USA

来源：

JOURNAL OF NUCLEAR MEDICINE | 2021年 / 62卷

关键词：

F-18-FDOPA; hyperinsulinism; congenital hyperinsulinism; POSITRON-EMISSION-TOMOGRAPHY; COMPUTED TOMOGRAPHY; DOPA DECARBOXYLASE; FOCAL FORM; DIAGNOSIS; INFANCY; ACCURACY; SCAN; LOCALIZATION; HYPOGLYCEMIA;

D O I：

10.2967/jnumed.120.246033

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Congenital hyperinsulinism is characterized by persistent hypoglycemia due to inappropriate excess secretion of insulin resulting in hyper-insulinemic hypoglycemia. The clinical course varies from mild to severe, with a significant risk for brain damage. Imaging plays a valuable role in the care of infants and children with severe hypoglycemia unresponsive to medical therapy. F-18-6-fluoro-L-dopa PET/CT is the method of choice for the detection and localization of a focal lesion of hyperinsulinism. Surgical resection of a focal lesion can lead to a cure with limited pancreatectomy. This article reviews the role of F-18-6-fluoro-L-dopa PET/CT in the management of this vulnerable population.

引用

页码：51S / 56S

页数：6

共 51 条

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