Synthesis and Biological Activities of Novel Pyrazole Amide Derivatives Containing Substituted Isoxazole Group

被引：7

作者：

Dai, Hong ^{[1
]}

Yao, Wei ^{[1
]}

Ye, Linyu ^{[1
]}

Fang, Yuan ^{[2
]}

Shi, Yujun ^{[1
,2
]}

Song, Chan ^{[1
]}

Li, Chunjian ^{[3
]}

Shi, Jian ^{[3
]}

机构：

[1] Nantong Univ, Coll Chem & Chem Engn, Nantong 226019, Peoples R China

[2] Jiangsu Univ Sci & Technol, Sch Environm & Chem Engn, Zhenjiang 212003, Peoples R China

[3] Nantong Univ, Anal & Testing Ctr, Nantong 226019, Peoples R China

来源：

CHINESE JOURNAL OF ORGANIC CHEMISTRY | 2017年 / 37卷 / 08期

基金：

中国国家自然科学基金;

关键词：

isoxazole; pyrazole; amide; synthesis; biological activity; CYANOACRYLATE DERIVATIVES; DESIGN; IDENTIFICATION; INHIBITORS; ANALOGS;

D O I：

10.6023/cjoc201702025

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

In order to find novel pyrazole compounds possessing potent biological activities, a series of novel pyrazole amide derivatives bearing substituted isoxazole moiety were designed and synthesized according to the method of active substructure combination. Their structures were confirmed by H-1 NMR, C-13 NMR and elemental analysis. The bioassay data indicated that some title compounds had good insecticidal activities. At the concentration of 500 mu g/mL, some compounds showed 60%similar to 100% insecticidal activity against Oriental armyworm, and 50%similar to 100% insecticidal activity against Aphis medicaginis. Additionally, some compounds exhibited good anti-cancer activity against HepG2 cells with the IC50 values of 14.2 similar to 18.9 mu mol/L.

引用

页码：2165 / 2171

页数：7

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