Bacterial death by DNA gyrase poisoning

被引：106
作者：
Couturier, M
Bahassi, E
Van Melderen, L
机构：
[1] Free Univ Brussels, Dept Biol Mol, Lab Genet Procaryotes, B-1640 Rhode St Genese, Belgium
[2] Univ Texas, SW Med Ctr, Dept Mol Biol & Oncol, Dallas, TX 75235 USA
来源：
TRENDS IN MICROBIOLOGY | 1998年 / 6卷 / 07期
关键词：
D O I：
10.1016/S0966-842X(98)01311-0
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
DNA gyrase is an essential topoisomerase that is found in all bacteria and is the target of potent antibiotics, such as the quinolones. By creating DNA lesions and inducing the bacterial SOS response, these drugs are not only highly cytotoxic but also mutagenic. Discovery and analysis of natural molecules with anti-gyrase activities, such as the CcdB or microcin B17 proteins, hold promise for understanding further topoisomerase reactions and for the design of new antibiotics.
引用
收藏
页码：269 / 275
页数：7
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