A NIR Turn-on Fluorescent Sensor For Detection of Chloride Ions in vitro and in vivo

被引：14

作者：

Zhang, Fengyuan ^{[1
,2
,3
]}

Ma, Chen ^{[1
,2
]}

Jiao, Zhijuan ^{[1
,2
]}

Mu, Shuai ^{[1
,2
]}

Zhang, Yida ^{[1
,2
]}

Liu, Xiaoyan ^{[1
,2
]}

Zhang, Haixia ^{[1
,2
]}

机构：

[1] Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China

[2] Lanzhou Univ, Coll Chem & Chem Engn, Lanzhou 730000, Peoples R China

[3] Ningxia Med Univ, Sch Basic Med Sci, Yinchuan 750004, Ningxia, Peoples R China

来源：

SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY | 2020年 / 228卷

基金：

中国国家自然科学基金;

关键词：

NIR turn-on sensor; Chloride ions; In vitro; In vivo; CHEMOSENSOR; PROBE; WATER; RECOGNITION; TRANSPORT; SULFIDE; COMPLEX; SHIFT;

D O I：

10.1016/j.saa.2019.117729

中图分类号：

O433 [光谱学];

学科分类号：

0703 ; 070302 ;

摘要：

As the most abundant and significant anions in biosystem, chloride ions (Cl-) participate in many important physiological processes. Thus, designing and synthesizing of a simple, sensitive, selective and long wavelength turn-on sensor for the detection and imaging of Cl- in vitro and in vivo is very necessary. Herein, we have developed a simple porphyrin turn-on sensor 5, 10, 15, 20-Tetrakis (4-hydroxyphenyl) porphyrin (THPP) with near infrared emission wavelength (657 nm) for sensing chloride ions with remarkable sensitivity and selectivity. The detection of chloride ions was according to metal displacement assay (MDA) under physiological condition with a detection limit of 7.5 mu M, and was applied to image Cl- in vitro and in vivo successfully. (C) 2019 Elsevier B.V. All rights reserved.

引用

页数：7

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