Chronic inflammation in the etiology of disease across the life span

被引：3020

作者：

Furman, David ^{[1
,2
,3
,4
]}

Campisi, Judith ^{[1
,5
]}

Verdin, Eric ^{[1
]}

Carrera-Bastos, Pedro ^{[6
]}

Targ, Sasha ^{[4
,7
]}

Franceschi, Claudio ^{[8
,9
,10
]}

Ferrucci, Luigi ^{[11
]}

Gilroy, Derek W. ^{[12
]}

Fasano, Alessio ^{[13
]}

Miller, Gary W. ^{[14
]}

Miller, Andrew H. ^{[15
]}

Mantovani, Alberto ^{[16
,17
,18
]}

Weyand, Cornelia M. ^{[19
]}

Barzilai, Nir ^{[20
,21
]}

Goronzy, Jorg J. ^{[22
]}

Rando, Thomas A. ^{[22
,23
,24
]}

Effros, Rita B. ^{[25
]}

Lucia, Alejandro ^{[26
,27
]}

Kleinstreuer, Nicole ^{[28
,29
]}

Slavich, George M. ^{[30
,31
]}

机构：

[1] Buck Inst Res Aging, Novato, CA 94945 USA

[2] Stanford Univ, Sch Med, Inst Immun Transplantat & Infect, Stanford 1000 Immunomes Project, Stanford, CA 94305 USA

[3] Univ Austral, CONICET, Inst Res Translat Med, Buenos Aires, DF, Argentina

[4] Iuve Inc, San Mateo, CA 94401 USA

[5] Lawrence Berkeley Natl Lab, Berkeley, CA USA

[6] Lund Univ, Skane Univ Hosp, Reg Skane, Ctr Primary Hlth Care Res, Malmo, Sweden

[7] Univ Calif San Francisco, Med Scientist Training Program, San Francisco, CA 94143 USA

[8] IRCCS Inst Neurol Sci Bologna, Bologna, Italy

[9] Lobachevsky Univ, Dept Appl Math, Nizhnii Novgorod, Russia

[10] Lobachevsky Univ, Lab Syst Biol Aging, Nizhnii Novgorod, Russia

[11] NIA, Translat Gerontol Branch, NIH, Baltimore, MD 21224 USA

[12] UCL, Div Med, Ctr Clin Pharmacol & Therapeut, London, England

[13] Harvard Med Sch, MassGen Hosp Children, Boston, MA 02115 USA

[14] Columbia Univ, Sch Publ Hlth, Dept Environm Hlth Sci, Med Ctr, New York, NY USA

[15] Emory Univ, Sch Med, Dept Psychiat & Behav Sci, Atlanta, GA USA

[16] Humanitas Clin & Res Ctr, Milan, Italy

[17] Humanitas Univ, Dept Biomed Sci, Milan, Italy

[18] Queen Mary Univ, Barts & London Sch Med, William Harvey Res Inst, London, England

[19] Stanford Univ, Dept Med, Div Immunol & Rheumatol, Stanford, CA 94305 USA

[20] Albert Einstein Coll Med, Dept Med, New York, NY USA

[21] Albert Einstein Coll Med, Dept Genet, New York, NY USA

[22] Stanford Univ, Sch Med, Paul F Glenn Ctr Biol Aging, Stanford, CA 94305 USA

[23] Vet Affairs Palo Alto Hlth Care Syst, Ctr Tissue Regenerat Repair & Restorat, Palo Alto, CA USA

[24] Stanford Univ, Sch Med, Dept Neurol & Neurol Sci, Stanford, CA 94305 USA

[25] Univ Calif Los Angeles, Dept Pathol, Los Angeles, CA 90024 USA

[26] Univ Europea Madrid, Fac Sport Sci, Madrid, Spain

[27] Hosp 12 Octubre I 12, Res Inst, Madrid, Spain

[28] NIEHS, Biostat & Computat Biol Branch, Div Intramural Res, NIH,Dept Hlth & Human Serv, POB 12233, Res Triangle Pk, NC 27709 USA

[29] NIEHS, NTP Interagency Ctr Evaluat Alternat Toxicol Meth, NIH, Dept Hlth & Human Serv, POB 12233, Res Triangle Pk, NC 27709 USA

[30] Univ Calif Los Angeles, Cousins Ctr Psychoneuroimmunol, Los Angeles, CA USA

[31] Univ Calif Los Angeles, Dept Psychiat & Biobehav Sci, Los Angeles, CA 90024 USA

来源：

NATURE MEDICINE | 2019年 / 25卷 / 12期

基金：

欧盟地平线“2020”; 美国国家卫生研究院; 英国惠康基金;

关键词：

C-REACTIVE PROTEIN; CORONARY-HEART-DISEASE; SUPPLEMENTATION LOWERS INFLAMMATION; ADIPOSE-TISSUE; IMMUNE-SYSTEM; SECRETORY PHENOTYPE; DIABETES-MELLITUS; PHYSICAL-ACTIVITY; HEALTH CONSEQUENCES; CELLULAR SENESCENCE;

D O I：

10.1038/s41591-019-0675-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Although intermittent increases in inflammation are critical for survival during physical injury and infection, recent research has revealed that certain social, environmental and lifestyle factors can promote systemic chronic inflammation (SCI) that can, in turn, lead to several diseases that collectively represent the leading causes of disability and mortality worldwide, such as cardiovascular disease, cancer, diabetes mellitus, chronic kidney disease, non-alcoholic fatty liver disease and autoimmune and neurodegenerative disorders. In the present Perspective we describe the multi-level mechanisms underlying SCI and several risk factors that promote this health-damaging phenotype, including infections, physical inactivity, poor diet, environmental and industrial toxicants and psychological stress. Furthermore, we suggest potential strategies for advancing the early diagnosis, prevention and treatment of SCI.

引用

页码：1822 / 1832

页数：11

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