Uridine derivatives from the seeds of Lepidium apetalum Willd. and their estrogenic effects

被引：14

作者：

Li, Meng ^{[1
,2
]}

Zeng, Mengnan ^{[1
,2
]}

Zhang, Zhiguang ^{[1
]}

Zhang, Jingke ^{[1
]}

Zhang, Beibei ^{[1
]}

Zhao, Xuan ^{[1
]}

Zheng, Xiaoke ^{[1
,2
]}

Feng, Weisheng ^{[1
,2
]}

机构：

[1] Henan Univ Chinese Med, Zhengzhou 450046, Henan, Peoples R China

[2] Collaborat Innovat Ctr Resp Dis Diag & Treatment, Dev Henan Prov, Zhengzhou 450046, Henan, Peoples R China

来源：

PHYTOCHEMISTRY | 2018年 / 155卷

关键词：

Lepidium apetalum Willd; Brassicaceae; Uridine derivatives; Estrogen-like effects and potential mechanisms; Phytoestrogens; FLAVONOID GLYCOSIDES; ACID;

D O I：

10.1016/j.phytochem.2018.07.013

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Ten uridine derivatives (lepidiumuridine B-K) were isolated from the seeds of Lepidium apetalum Willd. Lepidiumuridine B-J were previously undescribed compounds, and were structurally characterized using analysis of their NMR and MS data. Lepidiumuridine C, D, I, and J increased cell proliferation and expression of ER alpha in the MCF-7 cell line. In addition, blockage of ER alpha completely abolished cell proliferation and expression of ERa in MCF-7 cells, suggesting that the proliferation effects of lepidiumuridine C, D, I, and J were ER alpha-mediated. The uridine derivatives might belong to undescribed phytoestrogens.

引用

页码：45 / 52

页数：8

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