Carotenoid mixtures protect multilamellar liposomes against oxidative damage: synergistic effects of lycopene and lutein

被引：261

作者：

Stahl, W

Junghans, A

de Boer, B

Driomina, ES

Briviba, K

Sies, H

机构：

[1] Univ Dusseldorf, Inst Physiol Chem 1, D-40001 Dusseldorf, Germany

[2] Univ Dusseldorf, Biol Med Forschungszentrum, D-40001 Dusseldorf, Germany

[3] Unilever Res Labs Vlaardingen, NL-3133 AT Vlaardingen, Netherlands

来源：

FEBS LETTERS | 1998年 / 427卷 / 02期

关键词：

alpha-tocopherol; lipid peroxidation; peroxyl radical; 2,2 '-azo-bis(2,4-dimethylvaleronitrile); antioxidant activity;

D O I：

10.1016/S0014-5793(98)00434-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Antioxidant activity of carotenoids in multilamellar liposomes assayed by inhibition of formation of thiobarbituric acid-reactive substances was in the ranking: lycopene > alpha-tocopherol > alpha-carotene > beta-cryptoxanthin > zeaxanthin = beta-carotene > lutein, Mixtures of carotenoids mere more effective than the single compounds. This synergistic effect was most pronounced when lycopene or lutein was present. The superior protection of mixtures may be related to specific positioning of different carotenoids in membranes. (C) 1998 Federation of European Biochemical Societies.

引用

页码：305 / 308

页数：4

共 26 条

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