A comprehensive overview of promising biomarkers in stage II colorectal cancer

被引：15

作者：

Parent, Pauline ^{[1
]}

Cohen, Romain ^{[2
,3
]}

Rassy, Elie ^{[4
,5
]}

Svrcek, Magali ^{[3
,6
]}

Taieb, Julien ^{[7
,8
]}

Andre, Thierry ^{[2
,3
]}

Turpin, Anthony ^{[1
,3
,7
,8
,9
]}

机构：

[1] Univ Lille, CHU Lille, Inst Pasteur Lille, CNRS,INSERM,UMR9020,UMR S 1277 Canther Canc Heter, Lille, France

[2] Hosp St Antoine, AP HP, Dept Med Oncol, 184 Rue Faubourg St Antoine, F-75012 Paris, France

[3] Univ Lille, CHU Lille, Med Oncol Dept, Lille, France

[4] Gustave Roussy, Dept Med Oncol, 114 Rue Edouard Vaillant, F-94800 Villejuif, France

[5] St Joseph Univ, Fac Med, Dept Med Oncol, Rue Damas, Beirut 175208, Lebanon

[6] Hosp St Antoine, AP HP, Dept Pathol, 184 Rue Faubourg St Antoine, F-75012 Paris, France

[7] Georges Pompidou European Hosp, Dept Gastroenterol & Gastrointestinal Oncol, 20 Rue Leblanc, F-75015 Paris, France

[8] Univ Paris, Sorbonne Paris Cite, AP HP, 2 Rue Albert Einstein, F-75013 Paris, France

[9] Claude Huriez Hosp, Dept Med Oncol, Rue Michel Polonovski, F-59000 Lille, France

来源：

CANCER TREATMENT REVIEWS | 2020年 / 88卷

关键词：

Colorectal cancer; Adjuvant chemotherapy; Artificial intelligence; Circulating Tumor DNA; Carcinoembryonic antigen; Immunoscore; MISMATCH REPAIR STATUS; CIRCULATING-TUMOR DNA; 12-GENE RECURRENCE SCORE; II/III COLON-CANCER; PROGNOSTIC IMPLICATIONS; MOLECULAR SUBTYPES; PREDICTIVE-VALUE; RISK; SURVIVAL; VALIDATION;

D O I：

10.1016/j.ctrv.2020.102059

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Colon cancer (CC) has the highest incidence rate among gastrointestinal cancers and ranks the third in mortality among all cancers, which contributes to the current CC burden and constitutes a major public health issue. While therapeutic strategies for stage I, III, and IV CC are standardized, those for stage II CC remain debatable. The choice of adjuvant chemotherapy for patients with stage II CC depends on stage (pT4) and grade (high) of the disease, the presence of venous, perinervous, and/or lymphatic emboli, or the need of suboptimal surgery (tumor with initial occlusion or perforation needing emergency surgeries, <12 lymph nodes harvested). Several prognostic factors that have been validated in retrospective studies can potentially define a population of CC patients at low and high-risk for reccurence. The role of biomarkers is becoming increasingly important for the future personalized treatment options. We conducted a systematic overview of potential prognostic biomarkers with possible clinical implications in stage II CC.

引用

页数：10

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