IGFBP2 Plays an Essential Role in Cognitive Development during Early Life

被引：22

作者：

Khan, Shumsuzzaman ^{[1
,2
]}

Lu, Xinjiang ^{[1
,2
]}

Huang, Qingyao ^{[1
,2
]}

Tang, Jiawei ^{[1
,2
]}

Weng, Jian ^{[1
,2
]}

Yang, Zhi ^{[1
,2
]}

Lv, Minchao ^{[1
,2
]}

Xu, Xiaokang ^{[1
,2
]}

Xia, Fangyuan ^{[1
,2
]}

Zhang, Mengchen ^{[1
,2
]}

Li, Yi ^{[1
,2
]}

Liu, Shuangshuang ^{[1
,2
]}

Leng, Gareth ^{[3
]}

Spitzer, Nicholas ^{[4
]}

Du, Jizeng ^{[1
,2
]}

Chen, Xuequn ^{[1
,2
]}

机构：

[1] Zhejiang Univ, Sch Med, Inst Neurosci, Dept Neurobiol, Hangzhou 310058, Peoples R China

[2] Zhejiang Univ, Dept Neurol, Affiliated Hosp 2, NHC&CAMS Key Lab Med Neurobiol,Key Lab Med Neurob, Hangzhou 310058, Peoples R China

[3] Univ Edinburgh, Expt Physiol, Edinburgh EH8 9XD, Midlothian, Scotland

[4] Univ Calif San Diego, La Jolla, CA 92093 USA

来源：

ADVANCED SCIENCE | 2019年 / 6卷 / 23期

基金：

中国国家自然科学基金;

关键词：

hippocampus; IGFBP2; IGFR1; learning and memory; neuropeptides; NEURONS; IGF1; TRANSMISSION; INHIBITION; EXPRESSION; SYNAPSES;

D O I：

10.1002/advs.201901152

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Identifying the mechanisms underlying cognitive development in early life is a critical objective. The expression of insulin-like growth factor binding protein 2 (IGFBP2) in the hippocampus increases during neonatal development and is associated with learning and memory, but a causal connection has not been established. Here, it is reported that neurons and astrocytes expressing IGFBP2 are distributed throughout the hippocampus. IGFBP2 enhances excitatory inputs onto CA1 pyramidal neurons, facilitating intrinsic excitability and spike transmission, and regulates plasticity at excitatory synapses in a cell-type specific manner. It facilitates long-term potentiation (LTP) by enhancing N-methyl-D-aspartate (NMDA) receptor-dependent excitatory postsynaptic current (EPSC), and enhances neurite proliferation and elongation. Knockout of igfbp2 reduces the numbers of pyramidal cells and interneurons, impairs LTP and cognitive performance, and reduces tonic excitation of pyramidal neurons that are all rescued by IGFBP2. The results provide insight into the requirement for IGFBP2 in cognition in early life.

引用

页数：14

共 38 条

[1] IGF-Binding Proteins: Why Do They Exist and Why Are There So Many? [J].