New short route to unsaturated fluoroketonucleosides:: Case of 5-fluoro-1-(6-O-acetyl-3,4-di-deoxy-3-fluoro-β-D-glycero-hex-3-eno-pyranos-2-ulosyl) uracil

被引：5
作者：
Egron, MJ
Komiotis, D
Dorange, I
Herscovici, J
Ollapally, AP
Antonakis, K
机构：
[1] Ecole Natl Super Chim Paris, CNRS, UMR 8151, F-75005 Paris, France
[2] Univ Thessaly, Dept Biochem & Biotechnol, Larisa, Greece
[3] Florida A&M Univ, Dept Chem, Tallahassee, FL 32307 USA
来源：
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS | 2005年 / 24卷 / 04期
关键词：
D O I：
10.1081/NCN-200059683
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The proposed short synthesis involves two key steps: Oxidation of the isopropylidene derivative of the 3 fluoronucleoside possessing a free hydroxyl group in 2-position and acetylation of deprotected 3-fluoro-2-ketonucleoside which, after a beta-elimination reaction, gives the desired unsaturated ketonucleoside 5.
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页码：243 / 246
页数：4
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