Effect of channel block on the spiking activity of excitable membranes in a stochastic Hodgkin-Huxley model

被引:114
作者
Schmid, G [1 ]
Goychuk, I [1 ]
Hänggi, P [1 ]
机构
[1] Univ Augsburg, Inst Phys, D-86135 Augsburg, Germany
关键词
D O I
10.1088/1478-3967/1/2/002
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The influence of intrinsic channel noise on the spontaneous spiking activity of poisoned excitable membrane patches is studied by use of a stochastic generalization of the Hodgkin-Huxley model. Internal noise stemming from the stochastic dynamics of individual ion channels is known to affect the collective properties of the whole ion channel cluster. For example, there exists an optimal size of the membrane patch for which the internal noise alone causes a regular spontaneous generation of action potentials. In addition to varying the size of ion channel clusters, living organisms may adapt the densities of ion channels in order to optimally regulate the spontaneous spiking activity. The influence of a channel block on the excitability of a membrane patch of a certain size is twofold: first, a variation of ion channel densities primarily yields a change of the conductance level; second, a down-regulation of working ion channels always increases the channel noise. While the former effect dominates in the case of sodium channel block resulting in a reduced spiking activity, the latter enhances the generation of spontaneous action potentials in the case of a tailored potassium channel blocking. Moreover, by blocking some portion of either potassium or sodium ion channels, it is possible to either increase or decrease the regularity of the spike train.
引用
收藏
页码:61 / 66
页数:6
相关论文
共 24 条
[1]   Spontaneous action potentials due to channel fluctuations [J].
Chow, CC ;
White, JA .
BIOPHYSICAL JOURNAL, 1996, 71 (06) :3013-3021
[2]   RELATIONSHIP BETWEEN MEMBRANE EXCITABILITY AND SINGLE CHANNEL OPEN-CLOSE KINETICS [J].
CLAY, JR ;
DEFELICE, LJ .
BIOPHYSICAL JOURNAL, 1983, 42 (02) :151-157
[3]   CHAOTIC STATES IN A RANDOM WORLD - RELATIONSHIP BETWEEN THE NONLINEAR DIFFERENTIAL-EQUATIONS OF EXCITABILITY AND THE STOCHASTIC PROPERTIES OF ION CHANNELS [J].
DEFELICE, LJ ;
ISAAC, A .
JOURNAL OF STATISTICAL PHYSICS, 1993, 70 (1-2) :339-354
[4]   EMERGENT COLLECTIVE BEHAVIOR IN LARGE NUMBERS OF GLOBALLY COUPLED INDEPENDENTLY STOCHASTIC ION CHANNELS [J].
FOX, RF ;
LU, YN .
PHYSICAL REVIEW E, 1994, 49 (04) :3421-3431
[5]   Stochastic resonance [J].
Gammaitoni, L ;
Hanggi, P ;
Jung, P ;
Marchesoni, F .
REVIEWS OF MODERN PHYSICS, 1998, 70 (01) :223-287
[6]   Global structure, robustness, and modulation of neuronal models [J].
Goldman, MS ;
Golowasch, J ;
Marder, E ;
Abbott, LF .
JOURNAL OF NEUROSCIENCE, 2001, 21 (14) :5229-5238
[7]  
HANGGI P, 1980, HELV PHYS ACTA, V53, P491
[8]  
Hänggi P, 2002, CHEMPHYSCHEM, V3, P285, DOI 10.1002/1439-7641(20020315)3:3<285::AID-CPHC285>3.0.CO
[9]  
2-A
[10]   STOCHASTIC-PROCESSES - TIME EVOLUTION, SYMMETRIES AND LINEAR RESPONSE [J].
HANGGI, P ;
THOMAS, H .
PHYSICS REPORTS-REVIEW SECTION OF PHYSICS LETTERS, 1982, 88 (04) :207-319