Influence of Nature of Functional Groups on Interaction of Tetrasubstituted at Lower Rim p-tert-Butyl Thiacalix[4]arenes in 1,3-Alternate Configuration with Model Lipid Membranes

被引：15

作者：

Fayzullin, D. A. ^{[1
]}

Vylegzhanina, N. N. ^{[1
]}

Gnezdilov, O. I. ^{[2
]}

Salnikov, V. V. ^{[1
]}

Galukhin, A. V. ^{[3
]}

Stoikov, I. I. ^{[3
]}

Antipin, I. S. ^{[3
]}

Zuev, Yu. F. ^{[1
]}

机构：

[1] Russian Acad Sci, Kazan Inst Biochem & Biophys, Kazan, Russia

[2] Russian Acad Sci, Zavoisky Phys Tech Inst, Kazan, Russia

[3] Kazan Volga Reg Fed Univ, Kazan, Russia

来源：

APPLIED MAGNETIC RESONANCE | 2011年 / 40卷 / 02期

基金：

俄罗斯基础研究基金会;

关键词：

FACILE SYNTHESIS; SULFUR; CALIXARENES; BUTYLPHENOL; N=4;

D O I：

10.1007/s00723-011-0202-z

中图分类号：

O64 [物理化学（理论化学）、化学物理学]; O56 [分子物理学、原子物理学];

学科分类号：

070203 ; 070304 ; 081704 ; 1406 ;

摘要：

The influence of p-tert-butyl thiacalix[4]arenes (1,3-alternate) functionalized by N-propyl morpholine, N, N-dipropyliden-amine and aminodiacetate fragments on dynamic structure of liposomal membranes prepared from dipalmitoyl phosphatidylcholine was investigated by means of electron spin resonance spin-probe technique and Fourier transform infrared spectroscopy. Nuclear magnetic resonance and transmission electron microscopy techniques were applied to characterize the interacting systems. The obtained results have shown that all studied calixarenes interact with polar domains of bilayer. Depending on functional groups and hydrophobic/hydrophilic properties of calixarenes they can dip into bilayer, locate close to the surface of bilayer or form bridges between positively charged groups of adjacent lipid molecules, thus assisting to disordering or putting in order the lipid molecules.

引用

页码：231 / 243

页数：13

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