Cellular regulation and proposed biological functions of group VIA calcium-independent phospholipase A2 in activated cells

被引：183

作者：

Balsinde, J ^{[1
]}

Balboa, MA ^{[1
]}

机构：

[1] Univ Valladolid, Sch Med, Inst Mol Biol & Genet, Eicosanoid Res Div, E-47005 Valladolid, Spain

来源：

CELLULAR SIGNALLING | 2005年 / 17卷 / 09期

关键词：

phospholipase A(2); arachidonic acids; eicosanoids; membrane phospholipid; Ca2+-independent; lysophospholipid; signal transduction;

D O I：

10.1016/j.cellsig.2005.03.002

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Mammalian cells contain several calcium-independent phospholipase A(2) (PLA(2)) enzymes. The best studied of them is the so-called Group VIA PLA(2) (iPLA(2)-VIA), which is an 85-88 kDa enzyme with unique structural features among the PLA(2) superfamily of enzymes, and has been found to play a key role in homeostatic membrane phospholipid metabolism in various cell types. Growing evidence suggests that, in addition to its homeostatic function, iPLA(2)-VIA may also play distinct roles in cellular signaling. This review focuses on the biochemical mechanisms that regulate the activity of iPLA(2)-VIA in activated cells, and the biological functions proposed for this enzyme during stimulus-response coupling. (c) 2005 Elsevier Inc. All rights reserved.

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页码：1052 / 1062

页数：11

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