Transdiagnostic Dysfunctions in Brain Modules Across Patients with Schizophrenia, Bipolar Disorder, and Major Depressive Disorder: A Connectome-Based Study

被引:84
作者
Ma, Qing [1 ,2 ,3 ]
Tang, Yanqing [4 ,5 ]
Wang, Fei [4 ,5 ]
Liao, Xuhong [1 ,2 ,3 ]
Jiang, Xiaowei [6 ]
Wei, Shengnan [6 ]
Mechelli, Andrea [7 ]
He, Yong [1 ,2 ,3 ]
Xia, Mingrui [1 ,2 ,3 ]
机构
[1] Beijing Normal Univ, Natl Key Lab Cognit Neurosci & Learning, Beijing, Peoples R China
[2] Beijing Normal Univ, Beijing Key Lab Brain Imaging & Connect, Beijing, Peoples R China
[3] Beijing Normal Univ, IDG McGovern Inst Brain Res, Beijing, Peoples R China
[4] China Med Univ, Affiliated Hosp 1, Dept Psychiat, Shenyang, Peoples R China
[5] China Med Univ, Affiliated Hosp 1, Brain Funct Res Sect, Shenyang, Peoples R China
[6] China Med Univ, Affiliated Hosp 1, Dept Radiol, Shenyang, Peoples R China
[7] Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Psychosis Studies, London, England
基金
中国国家自然科学基金;
关键词
graph theory; brain network; resting-state fMRI; modularity; connector; DEFAULT MODE NETWORK; FUNCTIONAL CONNECTIVITY; PREFRONTAL CORTEX; PSYCHOSIS; PSYCHOPATHOLOGY; DYSCONNECTIVITY; HALLUCINATIONS; ORGANIZATION; RISK; MRI;
D O I
10.1093/schbul/sbz111
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Psychiatric disorders, including schizophrenia (SCZ), bipolar disorder (BD), and major depressive disorder (MDD), share clinical and neurobiological features. Because previous investigations of functional dysconnectivity have mainly focused on single disorders, the transdiagnostic alterations in the functional connectome architecture of the brain remain poorly understood. We collected resting-state functional magnetic resonance imaging data from 512 participants, including 121 with SCZ, 100 with BD, 108 with MDD, and 183 healthy controls. Individual functional brain connectomes were constructed in a voxelwise manner, and the modular architectures were examined at different scales, including (1) global modularity, (2) module-specific segregation and intra- and intermodular connections, and (3) nodal participation coefficients. The correlation of these modular measures with clinical scores was also examined. We reliably identify common alterations in modular organization in patients compared to controls, including (1) lower global modularity; (2) lower modular segregation in the frontoparietal, subcortical, visual, and sensorimotor modules driven by more intermodular connections; and (3) higher participation coefficients in several network connectors (the dorsolateral prefrontal cortex and angular gyrus) and the thalamus. Furthermore, the alterations in the SCZ group are more widespread than those of the BD and MDD groups and involve more intermodular connections, lower modular segregation and higher connector integrity. These alterations in modular organization significantly correlate with clinical scores in patients. This study demonstrates common hyper-integrated modular architectures of functional brain networks among patients with SCZ, BD, and MDD. These findings reveal a transdiagnostic mechanism of network dysfunction across psychiatric disorders from a connectomic perspective.
引用
收藏
页码:699 / 712
页数:14
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