Delivery of Various Cargos into Cancer Cells and Tissues via Cell-Penetrating Peptides: A Review of the Last Decade

被引:32
作者
Shoari, Alireza [1 ,2 ]
Tooyserkani, Raheleh [1 ,2 ]
Tahmasebi, Mehdi [1 ]
Lowik, Dennis W. P. M. [2 ]
机构
[1] Tarbiat Modares Univ, Dept Med Biotechnol, Fac Med Sci, Tehran 14115111, Iran
[2] Radboud Univ Nijmegen, Inst Mol & Mat, Bioorgan Chem, Heyendaalseweg 135, NL-6525 AJ Nijmegen, Netherlands
关键词
cell-penetrating peptides; drug delivery; cancer; cargos; therapeutic molecules; DRUG-DELIVERY; ANTICANCER ACTIVITY; IN-VIVO; SYMMETRICAL DIMETHYLATION; DOXORUBICIN CONJUGATE; ANTITUMOR EFFICACY; SIRNA DELIVERY; TRANSPORTAN; 10; VIRAL VECTORS; NUCLEIC-ACID;
D O I
10.3390/pharmaceutics13091391
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Cell-penetrating peptides (CPPs), also known as protein transduction domains, are a class of diverse amino acid sequences with the ability to cross cellular membranes. CPPs can deliver several bioactive cargos, including proteins, peptides, nucleic acids and chemotherapeutics, into cells. Ever since their discovery, synthetic and natural CPPs have been utilized in therapeutics delivery, gene editing and cell imaging in fundamental research and clinical experiments. Over the years, CPPs have gained significant attention due to their low cytotoxicity and high transduction efficacy. In the last decade, multiple investigations demonstrated the potential of CPPs as carriers for the delivery of therapeutics to treat various types of cancer. Besides their remarkable efficacy owing to fast and efficient delivery, a crucial benefit of CPP-based cancer treatments is delivering anticancer agents selectively, rather than mediating toxicities toward normal tissues. To obtain a higher therapeutic index and to improve cell and tissue selectivity, CPP-cargo constructions can also be complexed with other agents such as nanocarriers and liposomes to obtain encouraging outcomes. This review summarizes various types of CPPs conjugated to anticancer cargos. Furthermore, we present a brief history of CPP utilization as delivery systems for anticancer agents in the last decade and evaluate several reports on the applications of CPPs in basic research and preclinical studies.
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页数:32
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