Tissue Contraction Caused by Radiofrequency and Microwave Ablation: A Laboratory Study in Liver and Lung

被引:138
作者
Brace, Christopher L. [1 ,2 ]
Diaz, Teresa A. [1 ]
Hinshaw, J. Louis [1 ]
Lee, Fred T., Jr. [1 ]
机构
[1] Univ Wisconsin, Dept Radiol, Madison, WI 53705 USA
[2] Univ Wisconsin, Dept Biomed Engn, Madison, WI 53705 USA
基金
美国国家卫生研究院;
关键词
VIVO PORCINE LIVER; IN-VIVO; COAGULATION NECROSIS; THERMAL ABLATION; TRIAXIAL ANTENNA; MODEL; METASTASES; COMPLICATIONS; CARCINOMA; ELECTRODE;
D O I
10.1016/j.jvir.2010.02.038
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
PURPOSE: To determine the amount of tissue contraction during radiofrequency (RF) and microwave ablation. MATERIALS AND METHODS: Markers were inserted into explanted bovine liver and lung 10 mm (inner), 20 mm (middle; not used in lung), and 30 mm (peripheral) diametrically around an ablation applicator. Aside from unablated controls, RF and microwave ablations 25-30 mm in diameter were then created and sectioned to measure the distance between markers (n = 12, liver RF; n = 8, other). Total contraction was calculated by subtracting postablation measurements from controls at each position. Relative contraction was calculated by subtracting the nearest more central measurement. Sample water content was measured to determine the relationship between dehydration and relative contraction. A mixed-effects model tested for differences in diameters, total and relative contraction, and water content with energy, tissue, and marker position as independent variables. RESULTS: Total contractions at the inner, middle, and peripheral positions in liver were 2.9 mm (31%), 4.8 mm (24%), and 4.5 mm (15%) for RF and 3.6 mm (38%), 6.6 mm (33%), and 9.0 mm (30%) for microwave, respectively. Significantly more contraction was noted in lung (P < .001): 5.1 mm (55%) and 14.2 mm (49%) for RF and 4.8 mm (52%) and 13.7 mm (47%) for microwave at the inner and peripheral positions, respectively. Microwaves produced more contraction than RF in liver (P < .05) but not in lung. A positive correlation between dehydration and relative contraction was observed in all cases. CONCLUSIONS: Ablation-induced tissue contraction is substantial and influenced by dehydration. Contraction should be considered when testing devices and computer models or comparing pre- and postablation images.
引用
收藏
页码:1280 / 1286
页数:7
相关论文
共 27 条
[1]  
AMIN V, 2008, C P IEEE ENG MED BIO, P4471
[2]   Microwave ablation with a single small-gauge triaxial antenna: In vivo porcine liver model [J].
Brace, Christopher L. ;
Laeseke, Paul F. ;
Sampson, Lisa A. ;
Frey, Tina M. ;
van der Weide, Daniel W. ;
Lee, Fred T., Jr. .
RADIOLOGY, 2007, 242 (02) :435-440
[3]   Pulmonary Thermal Ablation: Comparison of Radiofrequency and Microwave Devices by Using Gross Pathologic and CT Findings in a Swine Model [J].
Brace, Christopher L. ;
Hinshaw, J. Louis ;
Laeseke, Paul F. ;
Sampson, Lisa A. ;
Lee, Fred T., Jr. .
RADIOLOGY, 2009, 251 (03) :705-711
[4]   Microwave ablation with a triaxial antenna:: Results in ex vivo bovine liver [J].
Brace, CL ;
Laeseke, PF ;
van der Weide, DW ;
Lee, FT .
IEEE TRANSACTIONS ON MICROWAVE THEORY AND TECHNIQUES, 2005, 53 (01) :215-220
[5]  
Cantwell CP, 2006, AM J ROENTGENOL, V186, pS244, DOI 10.2214/AJR.04.0938
[6]   Radio-frequency tissue ablation of the liver: in vivo and ex vivo experiments with four different systems [J].
Denys, AL ;
De Baere, T ;
Kuoch, V ;
Dupas, B ;
Chevallier, P ;
Madoff, DC ;
Schnyder, P ;
Doenz, F .
EUROPEAN RADIOLOGY, 2003, 13 (10) :2346-2352
[7]   An experimental evaluation of ablation devices for the local treatment of the liver resection edge [J].
Gananadha, S ;
Daniel, S ;
Zhao, J ;
Morris, DL .
EJSO, 2005, 31 (05) :528-532
[8]   Immediate renal tumor involution after radiofrequency thermal ablation [J].
Ganguli, Suvranu ;
Brennan, Darren D. ;
Faintuch, Salomao ;
Rayan, Mostafa E. ;
Goldberg, S. Nahum .
JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY, 2008, 19 (03) :412-418
[9]   Radiofrequency ablation of primary and metastatic liver tumors: a critical review of the literature [J].
Garrean, Sean ;
Hering, Justin ;
Saied, Abdul ;
Helton, W. Scott ;
Espat, N. Joseph .
AMERICAN JOURNAL OF SURGERY, 2008, 195 (04) :508-520
[10]   Image-guided Tumor Ablation: Standardization of Terminology and Reporting Criteria (Reprinted from J Vasc Interv Radiol, vol 16, pg 765-778, 2005) [J].
Goldberg, S. Nahum ;
Grassi, Clement J. ;
Cardella, John F. ;
Charboneau, J. William ;
Dodd, Gerald D., III ;
Dupuy, Damian E. ;
Gervais, Debra A. ;
Gillams, Alice R. ;
Kane, Robert A. ;
Lee, Fred T., Jr. ;
Livraghi, Tito ;
McGahan, John ;
Phillips, David A. ;
Rhim, Hyunchul ;
Silverman, Stuart G. ;
Solbiati, Luigi ;
Vogl, Thomas J. ;
Wood, Bradford J. ;
Vedantham, Suresh ;
Sacks, David .
JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY, 2009, 20 (07) :S377-S390