Clinical and immunologic aspects of cytomegalovirus infection in solid organ transplant recipients

被引：146

作者：

Rowshani, AT

Bemelman, FJ

van Leeuwen, EMM

van Lier, RAW

ten Berge, IJM

机构：

[1] Univ Amsterdam, Acad Med Ctr, Dept Internal Med, Div Clin Immunol & Rheumatol, NL-1100 DE Amsterdam, Netherlands

[2] Acad Med Ctr, Div Nephrol, Amsterdam, Netherlands

[3] Acad Med Ctr, Dept Expt Immunol, Amsterdam, Netherlands

来源：

TRANSPLANTATION | 2005年 / 79卷 / 04期

关键词：

cytomegalovirus; solid organ transplantation; immune response; renal transplantation; antiviral therapy;

D O I：

10.1097/01.TP.0000148239.00384.F0

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Primary cytomegalovirus (CMV) infection is a major cause of morbidity and mortality in recipients after solid organ transplantation (SOT). Widespread and prolonged use of antiviral drugs has changed the natural course of CMV disease by delaying its onset and causing drug resistance. CMV induces a strong cellular immune response, even in immunosuppressed patients, and has developed strategies to evade this immune surveillance. This review summarizes challenges in managing CMV infection in transplant recipients and highlights current insights in the cellular immune response against CMV.

引用

页码：381 / 386

页数：6

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